Evidence map›Paper›PMID 34612092›Full record

Trial reportAIDS care2022

Point-of-care viral load testing among adolescents and young adults living with HIV in Haiti: a randomized control trial.

Lindsey K Reif, Marie Elmase Belizaire, Vanessa Rouzier, Grace Seo, Patrice Severe, Joseph-Marie Bajo Joseph, Bernadette Joseph, Sandra Apollon, Jean W Pape, Margaret L McNairy and 5 more

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in AIDS care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Clinical Outcomes in a Randomized Controlled Trial Comparing Point-of-Care With Standard Human Immunodeficiency Virus (HIV) Viral Load Monitoring in Nigeria.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Trial
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Lindsey K ReifDepartment of Medicine, Center for Global Health, Weill Cornell Medicine, New York, NY, USA.
Marie Elmase BelizaireGHESKIO Center, Port-au-Prince, Haiti.
Vanessa RouzierDepartment of Medicine, Center for Global Health, Weill Cornell Medicine, New York, NY, USA.
Grace SeoDepartment of Medicine, Center for Global Health, Weill Cornell Medicine, New York, NY, USA.
Patrice SevereGHESKIO Center, Port-au-Prince, Haiti.
Joseph-Marie Bajo JosephGHESKIO Center, Port-au-Prince, Haiti.
Bernadette JosephGHESKIO Center, Port-au-Prince, Haiti.
Sandra ApollonGHESKIO Center, Port-au-Prince, Haiti.
Jean W PapeDepartment of Medicine, Center for Global Health, Weill Cornell Medicine, New York, NY, USA.
Margaret L McNairyDepartment of Medicine, Center for Global Health, Weill Cornell Medicine, New York, NY, USA.
Batya ElulDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
Daniel W FitzgeraldDepartment of Medicine, Center for Global Health, Weill Cornell Medicine, New York, NY, USA.
Stephen M ArpadiICAP at Columbia University, Mailman School of Public Health, Columbia University, NY, USA.
Elaine J AbramsICAP at Columbia University, Mailman School of Public Health, Columbia University, NY, USA.
Louise KuhnGertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Gheskio Centers · HTColumbia University · USWeill Cornell Medicine · USCenter for Global Health · USICAP Global Health

Funding

Disparities in COVID Disease Severity and Outcomes in New York CityUL1TR002384 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JULIANNE L IMPERATO-MCGINLEY · 2017 to 2026
$86.2M
GHESKIO HIV Clinical Trial UnitUM1AI069421 · NIAID · GHESKIO CENTER · PI JEAN WILLIAM PAPE · 2012 to 2026
$23.6M
Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep DisordersR01HL143788 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Margaret Leighton McNairy · 2018 to 2026
$8.9M
GHESKIO HIV Clinical Trial UnitU01AI069421 · NIAID · GHESKIO CENTER · PI PAPE, JEAN WILLIAM · 2007 to 2011
$8.4M
Global Health Research Training in HIV and TuberculosisK24AI098627 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI FITZGERALD, DANIEL W · 2012 to 2022
$1.8M
Research Training Program in Adolescent HIV in HaitiD43TW011295 · FIC · GHESKIO CENTER · PI PAPE, JEAN WILLIAM · 2020 to 2024
$1.6M
FIC NIH HHS D43 TW011295NCATS NIH HHS UL1 TR002384NHLBI NIH HHS R01 HL143788NIAID NIH HHS K24 AI098627NIAID NIH HHS U01 AI069421NIAID NIH HHS UM1 AI069421
6 · The paper itself

Abstract

HIV viral load (VL) monitoring can reinforce antiretroviral therapy (ART) adherence. Standard VL testing requires high laboratory capacity and coordination between clinic and laboratory which can delay results. A randomized trial comparing point-of-care (POC) VL testing to standard VL testing among 150 adolescents and young adults, ages 10-24 years, living with HIV in Haiti determined if POC VL testing could return faster results and improve ART adherence and viral suppression. Participants received a POC VL test with same-day result (POC arm) or a standard VL test with result given 1 month later (SOC arm). POC arm participants were more likely to receive a test result within 6 weeks than SOC arm participants (94.7% vs. 80.1%; p1000 copies/ml and low self-reported ART adherence was stronger in the POC arm (OR: 6.57; 95%CI: 2.12-25.21) than the SOC arm (OR: 2.62; 95%CI: 0.97-7.44) suggesting more accurate self-report in the POC arm. POC VL testing was effectively implemented in this low-resource setting with faster results and is a pragmatic intervention that may enable clinicians to identify those with high VL to provide enhanced counseling or regimen changes sooner.

Indexed as

Anti-HIV AgentsHIV InfectionsAdolescentAdultAnti-Retroviral AgentsChildHaitiHumansPoint-of-Care SystemsViral LoadYoung AdultAnti-HIV AgentsAnti-Retroviral AgentsadherenceAdolescentHIVRCTviral suppressionyouth

Identifiers

PMID34612092
PMCPMC8976702
OpenAlexW3204428373

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.