Evidence map›Paper›PMID 34612088›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2021

Sex-specific effects of neonatal oral sucrose treatment on growth and liver choline and glucocorticoid metabolism in adulthood.

Cynthia Y Ramírez-Contreras, Arya E Mehran, Melody Salehzadeh, Ei-Xia Mussai, Joshua W Miller, Andre Smith, Manon Ranger, Liisa Holsti, Kiran K Soma, Angela M Devlin

Abstract readComparative Study
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Long-term effects of neonatal pain and sucrose treatment.Current research in pharmacology and drug discovery · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Cynthia Y Ramírez-ContrerasDepartment of Pediatrics, The University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0001-7831-4884
Arya E MehranDepartment of Pediatrics, The University of British Columbia, Vancouver, British Columbia, Canada.
Melody SalehzadehDepartment of Psychology, The University of British Columbia, Vancouver, British Columbia, Canada.
Ei-Xia MussaiBC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.
Joshua W MillerDepartment of Nutritional Sciences, Rutgers University, The State University of New Jersey, New Brunswick, New Jersey.ORCID 0000-0002-9126-0224
Andre SmithDepartment of Nutritional Sciences, Rutgers University, The State University of New Jersey, New Brunswick, New Jersey.ORCID 0000-0003-1347-3520
Manon RangerBC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.
Liisa HolstiBC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.
Kiran K SomaBC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.
Angela M DevlinDepartment of Pediatrics, The University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-1390-6587
University of British Columbia · CARutgers, The State University of New Jersey · US

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI BRIAN T BUCKLEY · 1988 to 2026
$47.4M
CIHRNIEHS NIH HHS P30 ES005022
6 · The paper itself

Abstract

Hospitalized preterm infants experience painful medical procedures. Oral sucrose is the nonpharmacological standard of care for minor procedural pain relief. Infants are treated with numerous doses of sucrose, raising concerns about potential long-term effects. The objective of this study was to determine the long-term effects of neonatal oral sucrose treatment on growth and liver metabolism in a mouse model. Neonatal female and male mice were randomly assigned to one of two oral treatments (

Indexed as

Administration, OralAge FactorsAnalgesicsAnimalsAnimals, NewbornBetaineCholineFemaleGlucocorticoidsGlycerylphosphorylcholineInsulin-Like Growth Factor ILiverMaleMiceMice, Inbred C57BLPhosphorylcholineAnalgesicsBetaineCholineGlucocorticoidsGlycerylphosphorylcholineinsulin-like growth factor-1, mouseInsulin-Like Growth Factor IPhosphorylcholineS-AdenosylmethionineSucrosecorticosteronedevelopmentinsulin-like growth factor 1neonatal paintibia length

Identifiers

PMID34612088
PMCPMC11961110
OpenAlexW3201808844

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.