Evidence map›Paper›PMID 34612085›Full record

ArticleJournal of the American Heart Association2021

Assessment of an ECG-Based System for Localizing Ventricular Arrhythmias in Patients With Structural Heart Disease.

Shijie Zhou, Amir AbdelWahab, John L Sapp, Eric Sung, Konstantinos N Aronis, James W Warren, Paul J MacInnis, Rushil Shah, B Milan Horáček, Ronald Berger and 3 more

Abstract readMulticenter Study
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. AI-Based QRS Onset Detection in the Early Ventricular Activation Site ECGs.IEEE journal of biomedical and health informatics · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Prognostic impact of morphology and duration of premature ventricular contractions in a population without structural heart disease.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2023
    Article
  6. Strain Imaging and Ventricular Arrhythmia.Diagnostics (Basel, Switzerland) · 2023
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shijie ZhouAlliance for Cardiovascular Diagnostic and Treatment Innovation Johns Hopkins University Baltimore MD.ORCID 0000-0002-6082-8921
Amir AbdelWahabDepartment of Medicine Queen Elizabeth II Health Sciences Centre Halifax NS Canada.ORCID 0000-0002-2410-6892
John L SappDepartment of Medicine Queen Elizabeth II Health Sciences Centre Halifax NS Canada.ORCID 0000-0002-9602-2751
Eric SungAlliance for Cardiovascular Diagnostic and Treatment Innovation Johns Hopkins University Baltimore MD.ORCID 0000-0001-9918-0133
Konstantinos N AronisDivision of Cardiology Department of Medicine Section of Cardiac Electrophysiology Johns Hopkins Hospital Baltimore MD.ORCID 0000-0001-7189-8434
James W WarrenDepartment of Physiology and Biophysics Dalhousie University Halifax NS Canada.
Paul J MacInnisDepartment of Physiology and Biophysics Dalhousie University Halifax NS Canada.
Rushil ShahDivision of Cardiology Department of Medicine Section of Cardiac Electrophysiology Johns Hopkins Hospital Baltimore MD.ORCID 0000-0002-8218-0206
B Milan HoráčekSchool of Biomedical Engineering Dalhousie University Halifax NS Canada.
Ronald BergerAlliance for Cardiovascular Diagnostic and Treatment Innovation Johns Hopkins University Baltimore MD.ORCID 0000-0002-7427-6750
Harikrishna TandriAlliance for Cardiovascular Diagnostic and Treatment Innovation Johns Hopkins University Baltimore MD.ORCID 0000-0003-2651-4352
Natalia A TrayanovaAlliance for Cardiovascular Diagnostic and Treatment Innovation Johns Hopkins University Baltimore MD.ORCID 0000-0002-8661-063X
Jonathan ChrispinAlliance for Cardiovascular Diagnostic and Treatment Innovation Johns Hopkins University Baltimore MD.ORCID 0000-0002-7985-3019

Funding

Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4M
Infarct-related Ventricular Tachycardia Mechanisms: From Micro to ClinicalR01HL142496 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TRAYANOVA, NATALIA A. · 2019 to 2022
$3.1M
Exploration of Arrhythmogenic Triggers and Substrates in Heart FailureR01HL126802 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI EFIMOV, IGOR R, GORELIK, JULIA · 2016 to 2019
$2.8M
NHLBI NIH HHS R01 HL126802NHLBI NIH HHS R01 HL142496NIGMS NIH HHS T32 GM136577
6 · The paper itself

Abstract

Background We have previously developed an intraprocedural automatic arrhythmia-origin localization (AAOL) system to identify idiopathic ventricular arrhythmia origins in real time using a 3-lead ECG. The objective was to assess the localization accuracy of ventricular tachycardia (VT) exit and premature ventricular contraction (PVC) origin sites in patients with structural heart disease using the AAOL system. Methods and Results In retrospective and prospective case series studies, a total of 42 patients who underwent VT/PVC ablation in the setting of structural heart disease were recruited at 2 different centers. The AAOL system combines 120-ms QRS integrals of 3 leads (III, V2, V6) with pace mapping to predict VT exit/PVC origin site and projects that site onto the patient-specific electroanatomic mapping surface. VT exit/PVC origin sites were clinically identified by activation mapping and/or pace mapping. The localization error of the VT exit/PVC origin site was assessed by the distance between the clinically identified site and the estimated site. In the retrospective study of 19 patients with structural heart disease, the AAOL system achieved a mean localization accuracy of 6.5±2.6 mm for 25 induced VTs. In the prospective study with 23 patients, mean localization accuracy was 5.9±2.6 mm for 26 VT exit and PVC origin sites. There was no difference in mean localization error in epicardial sites compared with endocardial sites using the AAOL system (6.0 versus 5.8 mm,

Indexed as

ElectrocardiographyTachycardia, VentricularVentricular Premature ComplexesCatheter AblationHumansProspective StudiesReproducibility of ResultsRetrospective StudiesECGpace‐mappingpremature ventricular contraction (PVC)radiofrequency (RF) ablationstructural heart disease (SHD)ventricular tachycardia (VT)

Identifiers

PMID34612085
PMCPMC8751877

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.