Evidence map›Paper›PMID 34612067›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2021

Melatonin MT

Haruka Sasaki, Yi Zhang, Charles W Emala, Kentaro Mizuta

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Predictive correlates of poor sleep associated with increased risk of severe asthma exacerbations among children with moderate-to-severe asthma.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Article
  3. Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Haruka SasakiDivision of Dento-oral Anesthesiology, Tohoku University Graduate School of Dentistry, Sendai, Japan.
Yi ZhangDepartment of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York.
Charles W EmalaDepartment of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York.
Kentaro MizutaDivision of Dento-oral Anesthesiology, Tohoku University Graduate School of Dentistry, Sendai, Japan.ORCID 0000-0001-8963-9844
Columbia University · USTohoku University · JP

Funding

Neuromuscular blocker-induced asthma during anesthesiaR01GM065281 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI EMALA, CHARLES W · 2003 to 2018
$5.4M
Novel nutriceuticals relax airway smooth muscle and decrease inflammation in allergic lung diseaseR01HL144852 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI EMALA, CHARLES W · 2020 to 2023
$1.9M
Targeting airway smooth muscle chloride fluxes for bronchorelaxationR01HL122340 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI EMALA, CHARLES W · 2015 to 2018
$1.6M
NHLBI NIH HHS R01 HL122340NHLBI NIH HHS R01 HL144852NIGMS NIH HHS R01 GM065281
6 · The paper itself

Abstract

Nocturnal asthma is characterized by heightened bronchial reactivity at night, and plasma melatonin concentrations are higher in patients with nocturnal asthma symptoms. Numerous physiological effects of melatonin are mediated via its specific G protein-coupled receptors (GPCRs) named the MT

Indexed as

Muscle ContractionMuscle RelaxationAcetylcholineAdultAnimalsAntioxidantsColforsinCyclic AMPGuinea PigsHumansMaleMelatoninMiddle AgedMyocytes, Smooth MuscleReceptor, Melatonin, MT2Respiratory SystemAcetylcholineAntioxidantsColforsinCyclic AMPMelatoninReceptor, Melatonin, MT2Vasodilator Agentsactincyclic AMPimmunohistochemistryintracellular calciumsiRNA

Identifiers

PMID34612067
PMCPMC8715028
OpenAlexW3201669328

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.