Evidence map›Paper›PMID 34612055›Full record

ArticleJournal of the American Heart Association2021

Dose of Cardiac Rehabilitation to Reduce Mortality and Morbidity: A Population-Based Study.

Jose R Medina-Inojosa, Sherry L Grace, Marta Supervia, Gorazd Stokin, Amanda R Bonikowske, Randal Thomas, Francisco Lopez-Jimenez

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 59 citations in OpenAlex.

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  16. Cardiac Rehabilitation After Open Heart Surgery: A Narrative Systematic Review.Journal of cardiovascular development and disease · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 4 countries.

Jose R Medina-InojosaDivision of Preventive Cardiology Department of Cardiovascular Medicine Mayo Clinic MN.ORCID 0000-0001-8705-0462
Sherry L GraceKITE & Peter Menk Cardiac Centre University Health NetworkUniversity of Toronto Toronto Ontario Canada.ORCID 0000-0001-7063-3610
Marta SuperviaDivision of Preventive Cardiology Department of Cardiovascular Medicine Mayo Clinic MN.ORCID 0000-0002-5178-8315
Gorazd StokinInternational Clinical Research Center St. Anne University Hospital Brno Czech Republic.ORCID 0000-0001-8430-8755
Amanda R BonikowskeDivision of Preventive Cardiology Department of Cardiovascular Medicine Mayo Clinic MN.ORCID 0000-0001-9317-4330
Randal ThomasDivision of Preventive Cardiology Department of Cardiovascular Medicine Mayo Clinic MN.ORCID 0000-0003-1448-7182
Francisco Lopez-JimenezDivision of Preventive Cardiology Department of Cardiovascular Medicine Mayo Clinic MN.ORCID 0000-0001-5788-9734
Mayo Clinic in Arizona · USHospital General Universitario Gregorio Marañón · ESMayo Clinic · USUniversity Health Network · CAUniversity Hospital Brno · CZWinnMed · US

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Interdisciplinary Infrastructure for Aging Research: Rochester Epidemiology ProjectR33AG058738 · NIA · MAYO CLINIC ROCHESTER · PI LEBRASSEUR, NATHAN K, OLSON, JANET E · 2020 to 2022
$2.4M
Interdisciplinary Infrastructure for Aging Research: Rochester Epidemiology ProjectR21AG058738 · NIA · MAYO CLINIC ROCHESTER · PI LEBRASSEUR, NATHAN K, OLSON, JANET E · 2018 to 2019
$437k
NCATS NIH HHS UL1 TR000135NIA NIH HHS R21 AG058738NIA NIH HHS R33 AG058738
6 · The paper itself

Abstract

Background There is wide variability in cardiac rehabilitation (CR) dose (ie, number of sessions) delivered, and no evidence-based recommendations regarding what dose to prescribe. We aimed to test what CR dose impacts major adverse cardiovascular events (MACEs). Methods and Results This is an historical cohort study of all patients who had coronary artery disease and who initiated supervised CR between 2002 and 2012 from a single major CR center. CR dose was defined as number of visits including exercise and patient education. Follow-up was performed using record linkage from the Rochester Epidemiology Project. MACEs included acute myocardial infarction, unstable angina, ventricular arrhythmias, stroke, revascularization, or all-cause mortality. Dose was analyzed in several ways, including tertiles, categories, and as a continuous variable. Cox models were adjusted for factors associated with dose and MACE. The cohort consisted of 2345 patients, who attended a mean of 12.5±11.1 of 36 prescribed sessions. After a mean follow-up of 6 years, 695 (29.65%) patients had a MACE, including 231 who died. CR dose was inversely associated with MACE (hazard ratio, 0.66 [95% CI]; 0.55-0.91) in those completing ≥20 sessions, when compared with those not exposed to formal exercise sessions (≤1 session; log-rank

Indexed as

Cardiac RehabilitationCoronary Artery DiseaseMyocardial InfarctionCohort StudiesHumansMorbiditycardiac rehabilitationmajor adverse cardiovascular eventsmortality

Identifiers

PMID34612055
PMCPMC8751887
OpenAlexW3202247279

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.