Evidence map›Paper›PMID 34612012›Full record

Trial reportJournal of cachexia, sarcopenia and muscle2021

A randomized, feasibility trial of an exercise and nutrition-based rehabilitation programme (ENeRgy) in people with cancer.

Charlie C Hall, Richard J E Skipworth, Honor Blackwood, Duncan Brown, Jane Cook, Katharina Diernberger, Elizabeth Dixon, Valerie Gibson, Catriona Graham, Peter Hall and 8 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of cachexia, sarcopenia and muscle, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Multimodal interventions for cachexia management.The Cochrane database of systematic reviews · 2025
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  6. Effect of modified Baduanjin exercise on nutritional status in patients with nasopharyngeal carcinoma: a randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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  16. Factors associated with multimodal care practices for cancer cachexia among registered dietitians.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Charlie C HallSt Columba's Hospice, Edinburgh, UK.
Richard J E SkipworthClinical Surgery, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK.
Honor BlackwoodSt Columba's Hospice, Edinburgh, UK.
Duncan BrownSt Columba's Hospice, Edinburgh, UK.
Jane CookSt Columba's Hospice, Edinburgh, UK.
Katharina DiernbergerInstitute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Elizabeth DixonSouthampton Clinical Trials Unit, University of Southampton, Southampton, UK.
Valerie GibsonSt Columba's Hospice, Edinburgh, UK.
Catriona GrahamEdinburgh Clinical Research Facility, University of Edinburgh, Edinburgh, UK.
Peter HallInstitute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Erna HaraldsdottirSt Columba's Hospice, Edinburgh, UK.
Jane HopkinsonCardiff University, Cardiff, UK.
Anna LloydSt Columba's Hospice, Edinburgh, UK.
Matthew MaddocksCicely Saunders Institute of Palliative Care, Policy and Rehabilitation, Kings College, London, UK.
Lucy NorrisInstitute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Sharon TuckEdinburgh Clinical Trials Unit, University of Edinburgh, Edinburgh, UK.
Marie T FallonInstitute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Barry J A LairdSt Columba's Hospice, Edinburgh, UK.ORCID 0000-0002-2807-6192

Funding

Cancer Research UK 25352Chief Scientist Office MCRGS-07-16-73Marie Curie MCCC-RP-15-A19005Marie Curie MCCC-RP-16-A20997Marie Curie MCRGS-07-16-73
6 · The paper itself

Abstract

backgroundDespite rehabilitation being increasingly advocated for people living with incurable cancer, there is limited evidence supporting efficacy or component parts. The progressive decline in function and nutritional in this population would support an approach that targets these factors. This trial aimed to assess the feasibility of an exercise and nutrition based rehabilitation programme in people with incurable cancer.

methodsWe randomized community dwelling adults with incurable cancer to either a personalized exercise and nutrition based programme (experimental arm) or standard care (control arm) for 8 weeks. Endpoints included feasibility, quality of life, physical activity (step count), and body weight. Qualitative and health economic analyses were also included.

resultsForty-five patients were recruited (23 experimental arm, 22 control arm). There were 26 men (58%), and the median age was 78 years (IQR 69-84). At baseline, the median BMI was 26 kg/m

conclusionsAn exercise and nutritional rehabilitation intervention is feasible and has potential benefits for people with incurable cancer. A larger trial is now warranted to test the efficacy of this approach.

Indexed as

ExerciseNeoplasmsNutritional StatusAgedAged, 80 and overFeasibility StudiesHumansMaleQuality of LifeCancerExerciseNutritionRehabilitation

Identifiers

PMID34612012
PMCPMC8718057

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.