ArticleAdvanced materials (Deerfield Beach, Fla.)2021
Optimized Photoclick (Bio)Resins for Fast Volumetric Bioprinting.
Article in Advanced materials (Deerfield Beach, Fla.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
- Rapid volumetric bioprinting of pristine protein-based (bio)inks.Nature protocols · 2026Review
- Tomographic Printing in a Chip: A Versatile Platform for Biomimetic 3D Organ-on-Chip.Advanced healthcare materials · 2026Article
- Single-exposure holographic 3D printing via inverse-designed phase masks.Science advances · 2026Article
- A robust and user-agnostic step-emulsion platform for scalable microgel fabrication.bioRxiv : the preprint server for biology · 2026Article
- 3D biofabricated in vitro models as new approach methodologies for animal alternatives.npj biomedical innovations · 2026Review
- Highly Tunable and Cell-Remodelable Thiol-ene Alginate-Peptide Crosslinked Hydrogels to Recreate Cellular and Organoid Microenvironments for Biofabrication.Advanced healthcare materials · 2026Article
- Acoustic Bioprinting: A Glimpse Into an Emerging Field.Small methods · 2026Review
- Prolonged Cell Encapsulation and Gravity-independent Filamented Light Biofabrication of Muscle Constructs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Hydrogel-based microfluidic model of the blood-brain barrier: progress and future perspectives.Fluids and barriers of the CNS · 2025Review
- Advanced cell-adaptable hydrogels for bioprinting.Bioactive materials · 2025Review
- 3D bioprinting bone/cartilage organoids: construction, applications, and challenges.Journal of orthopaedic translation · 2025Review
- Rapid Deep Vat Printing Using Photoclickable Collagen-Based Bioresins.Advanced healthcare materials · 2025Article
- Bidirectional mechanisms and emerging strategies for implantable bioelectronic interfaces.Bioactive materials · 2025Review
- Mechanism Inversion in Visible Light-Induced Photoclick Reactions.Journal of the American Chemical Society · 2025Article
- Vat Photopolymerization of Smart Polymers for Biomedical Applications.ACS applied polymer materials · 2025Review
- Structured Light Projection Using Image Guide Fibers for In Situ Photo-biofabrication.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Volumetric printed biomimetic scaffolds support in vitro lactation of human milk-derived mammary epithelial cells.Science advances · 2025Article
- Engineering a Fusion Protein Biomaterial Based on SpyTag/SpyCatcher Bioconjugation of Elastin and Collagen Synthetic Proteins.ACS omega · 2025Article
- Filamented hydrogels as tunable conduits for guiding neurite outgrowth.Materials today. Bio · 2025Article
- A Comparative Study between Thiol-Ene and Acrylate Photocrosslinkable Hyaluronic Acid Hydrogel Inks for Digital Light Processing.Macromolecular bioscience · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Volumetric printing (VP) is a light-mediated technique enabling printing of complex, low-defect 3D objects within seconds, overcoming major drawbacks of layer-by-layer additive manufacturing. An optimized photoresin is presented for VP in the presence of cells (volumetric bioprinting) based on fast thiol-ene step-growth photoclick crosslinking. Gelatin-norbornene (Gel-NB) photoresin shows superior performance, both in physicochemical and biocompatibility aspects, compared to (meth-)acryloyl resins. The extremely efficient thiol-norbornene reaction produces the fastest VP reported to date (≈10 s), with significantly lower polymer content, degree of substitution (DS), and radical species, making it more suitable for cell encapsulation. This approach enables the generation of cellular free-form constructs with excellent cell viability (≈100%) and tissue maturation potential, demonstrated by development of contractile myotubes. Varying the DS, polymer content, thiol-ene ratio, and thiolated crosslinker allows fine-tuning of mechanical properties over a broad stiffness range (≈40 Pa to ≈15 kPa). These properties are achieved through fast and scalable methods for producing Gel-NB with inexpensive, off-the-shelf reagents that can help establish it as the gold standard for light-mediated biofabrication techniques. With potential applications from high-throughput bioprinting of tissue models to soft robotics and regenerative medicine, this work paves the way for exploitation of VPs unprecedented capabilities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.