Evidence map›Paper›PMID 34611923›Full record

ArticleMagnetic resonance in medicine2022

Pilot tone navigation for respiratory and cardiac motion-resolved free-running 5D flow MRI.

Mariana B L Falcão, Lorenzo Di Sopra, Liliana Ma, Mario Bacher, Jérôme Yerly, Peter Speier, Tobias Rutz, Milan Prša, Michael Markl, Matthias Stuber and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Fully self-gated dual-venc five-dimensional flow magnetic resonance imaging for simultaneous imaging of the cardiovascular and portal venous systems: A feasibility study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2026
    Article
  3. Article
  4. Article
  5. Comparison of free-running whole-heart five-dimensional and four-dimensional flow imaging to standard two-dimensional flow in patients with congenital heart disease.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2026
    Article
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  7. Article
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  9. Article
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  11. Article
  12. Review
  13. Article
  14. Article
  15. Combined free-running four-dimensional anatomical and flow magnetic resonance imaging with native contrast using Synchronization of Neighboring Acquisitions by Physiological Signals.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2024
    Article
  16. Cardiac and respiratory motion extraction for MRI using pilot tone-a patient study.The international journal of cardiovascular imaging · 2024
    Article
  17. 4D Flow cardiovascular magnetic resonance consensus statement: 2023 update.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023
    Review
  18. Article
  19. Article
  20. External Hardware and Sensors, for Improved MRI.Journal of magnetic resonance imaging : JMRI · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Mariana B L FalcãoDepartment of Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.ORCID 0000-0002-4996-0331
Lorenzo Di SopraDepartment of Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.ORCID 0000-0003-3426-9457
Liliana MaDepartment of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.ORCID 0000-0001-8834-8519
Mario BacherDepartment of Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.ORCID 0000-0002-5529-3598
Jérôme YerlyDepartment of Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.ORCID 0000-0003-4347-8613
Peter SpeierSiemens Healthcare GmbH, Erlangen, Germany.ORCID 0000-0003-0449-1145
Tobias RutzService of Cardiology, Centre de Resonance Magnétique Cardiaque (CRMC), Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0001-5899-291X
Milan PršaWoman-Mother-Child Department, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-9483-7957
Michael MarklDepartment of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Matthias StuberDepartment of Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.ORCID 0000-0001-9843-2028
Christopher W RoyDepartment of Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.ORCID 0000-0002-3111-8840
University of Lausanne · CHCentre d'Imagerie BioMedicale · CHNorthwestern University · USSiemens Healthineers (Germany) · DE

Funding

Functional Cardiovascular 4D MRI in Congenital Heart DiseaseR01HL115828 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MARKL, MICHAEL, RIGSBY, CYNTHIA K · 2012 to 2021
$5.2M
4D Flow MRI-based assessment of atrial fibrillationF30HL137279 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MA, LILIANA · 2017 to 2020
$189k
NHLBI NIH HHS F30 HL137279NHLBI NIH HHS R01 HL115828
6 · The paper itself

Abstract

purposeIn this work, we integrated the pilot tone (PT) navigation system into a reconstruction framework for respiratory and cardiac motion-resolved 5D flow. We tested the hypotheses that PT would provide equivalent respiratory curves, cardiac triggers, and corresponding flow measurements to a previously established self-gating (SG) technique while being independent from changes to the acquisition parameters.

methodsFifteen volunteers and 9 patients were scanned with a free-running 5D flow sequence, with PT integrated. Respiratory curves and cardiac triggers from PT and SG were compared across all subjects. Flow measurements from 5D flow reconstructions using both PT and SG were compared to each other and to a reference electrocardiogram-gated and respiratory triggered 4D flow acquisition. Radial trajectories with variable readouts per interleave were also tested in 1 subject to compare cardiac trigger quality between PT and SG.

resultsThe correlation between PT and SG respiratory curves were 0.95 ± 0.06 for volunteers and 0.95 ± 0.04 for patients. Heartbeat duration measurements in volunteers and patients showed a bias to electrocardiogram measurements of, respectively, 0.16 ± 64.94 ms and 0.01 ± 39.29 ms for PT versus electrocardiogram and of 0.24 ± 63.68 ms and 0.09 ± 32.79 ms for SG versus electrocardiogram. No significant differences were reported for the flow measurements between 5D flow PT and from 5D flow SG. A decrease in the cardiac triggering quality of SG was observed for increasing readouts per interleave, whereas PT quality remained constant.

conclusionPT has been successfully integrated in 5D flow MRI and has shown equivalent results to the previously described 5D flow SG technique, while being completely acquisition-independent.

Indexed as

HeartMagnetic Resonance ImagingElectrocardiographyHumansMotionRespirationRespiratory Rate5D flow MRIcardiac motionfree-runningpilot tonerespiratory motion

Identifiers

PMID34611923
PMCPMC8627452
OpenAlexW3202337699

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.