Evidence map›Paper›PMID 34611918›Full record

ArticleThe International journal of eating disorders2021

Clinician practices assessing hypothalamic-pituitary-gonadal axis suppression in adolescents with an eating disorder.

Lance R Nelson, Bonnie L Halpern-Felsher, Jason M Nagata, Jennifer L Carlson

Abstract read
In one paragraph

Article in The International journal of eating disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Emotion Regulation as a Predictor of Disordered Eating Symptoms in Young Female University Students.European journal of investigation in health, psychology and education · 2025
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lance R NelsonDivision of Adolescent Medicine, Department of Pediatrics, Stanford University, Palo Alto, California, USA.ORCID 0000-0002-6511-5226
Bonnie L Halpern-FelsherDivision of Adolescent Medicine, Department of Pediatrics, Stanford University, Palo Alto, California, USA.
Jason M NagataDivision of Adolescent and Young Adult Medicine, Department of Pediatrics, University of California, San Francisco, California, USA.
Jennifer L CarlsonDivision of Adolescent Medicine, Department of Pediatrics, Stanford University, Palo Alto, California, USA.

Funding

Informing national guidelines on adolescent and young adult physical activity and sedentary behavior to prevent cardiovascular diseaseK08HL159350 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NAGATA, JASON M · 2021 to 2025
$869k
NHLBI NIH HHS K08 HL159350NIH HHS K08HL159350
6 · The paper itself

Abstract

objectiveAlthough extensive literature exists on hypothalamic-pituitary-gonadal (HPG) axis suppression in females with an eating disorder, there are few studies in males. Our study aimed to determine clinician practices for the assessment of HPG axis suppression and to identify differences in practice based on the sex of the patient.

methodOur 31-item survey queried clinicians about confidence level and practices for assessing HPG suppression in male compared to female patients.

resultsFindings showed that clinicians (n = 104) were less likely to evaluate HPG suppression in males compared to females, including assessment of sexual maturity rating (p < .050), screening of decreased libido compared to amenorrhea (p < .001) and lab assessment (luteinizing hormone and follicular-stimulating hormone: p < .001; estradiol/testosterone: p < .010; TSH: p < .050). Participants also felt less confident evaluating male patients (p < .001) and requested better screening tools for males (p < .001). DISCUSSION: Our data suggest that clinician practices differ based on patient sex and that clinicians request tools for HPG suppression assessment in males. This is the first study examining specific practices and comfort levels of clinicians when assessing HPG axis suppression. Findings suggest that more guidance on the management of male patients may be needed to standardize care and to prevent short and long-term sequela of malnutrition.

Indexed as

Feeding and Eating DisordersHypothalamo-Hypophyseal SystemAdolescentEstradiolFemaleHumansLuteinizing HormoneMaleTestosteroneEstradiolLuteinizing HormoneTestosteroneadolescentclinician comfortclinician practiceseating disordershypothalamic-pituitary-gonadal axismalesscreeningsex differences

Identifiers

PMID34611918
PMCPMC11378747

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.