ArticleJournal of the American Geriatrics Society2022
Changes in older adults' life space during lung cancer treatment: A mixed methods cohort study.
Article in Journal of the American Geriatrics Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Experience of patients considering or using checkpoint inhibitors in cancer treatment: a systematic review of qualitative research.Journal for immunotherapy of cancer · 2024Pooled it
- Using Patient-Reported Outcome Measures to Identify Mobility Limitation in Incurable Cancer.Archives of rehabilitation research and clinical translation · 2026Article
- Uncovering the realities of suicidal ideation in older patients following lung cancer diagnosis: an interpretive phenomenological qualitative study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Associations of frailty with survival, hospitalization, functional decline, and toxicity among older adults with advanced non-small cell lung cancer.The oncologist · 2025Article
- Survivorship outcomes in patients treated with immune checkpoint inhibitors: a scoping review.Journal of cancer survivorship : research and practice · 2025Article
- Daily life mobility detects frailty, falls, and functioning in older prostate cancer survivors treated with androgen deprivation therapy.Journal of geriatric oncology · 2025Article
- Function, cognition, and quality of life among older adults with lung cancer who live alone: A prospective cohort study.Journal of geriatric oncology · 2024Article
- Receipt of financial assistance for oral targeted therapy among older adults with advanced non-small cell lung cancer: A prospective cohort study.Journal of geriatric oncology · 2024Article
- Benefit-finding profiles and comparison of caregiving ability among informal caregivers of patients with lung cancer: A latent profile analysis.Asia-Pacific journal of oncology nursing · 2024Article
- Restricted life-space mobility impacts physical but not mental quality of life in older cancer survivors.Cancer medicine · 2024Article
- The FITNESS study: longitudinal geriatric assessment, treatment toxicity, and biospecimen collection to assess functional disability among older adults with lung cancer.Frontiers in aging · 2024Article
- Change in four measures of physical function among older adults during lung cancer treatment: A mixed methods cohort study.Journal of geriatric oncology · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
19 authors at 9 institutions in 1 country.
Funding
Abstract
backgroundMaintenance of function during cancer treatment is important to older adults. Characteristics associated with pretreatment life-space mobility and changes during non-small cell lung cancer (NSCLC) treatment remain unknown.
methodsThis mixed methods cohort study recruited adults age ≥65 with advanced NSCLC starting palliative chemotherapy, immunotherapy, and/or targeted therapy from a Comprehensive Cancer Center, Veterans Affairs, and safety-net clinic. Patients completed geriatric assessments including Life-Space Assessment (LSA) pretreatment and at 1, 2, 4, and 6 months after treatment initiation. LSA scores range from 0 to 120 (greater mobility); LSA <60 is considered restricted. We used mixed-effects models to examine pretreatment LSA, change from 0 to 1 month, and change from 1 to 6 months. A subgroup participated in semistructured interviews pretreatment and at 2 and 6 months to understand the patient experience of life-space change. For each interview participant, we created joint displays of longitudinal LSA scores juxtaposed with illustrative quotes.
resultsAmong 93 patients, median age was 73 (range 65-94). Mean pretreatment LSA score was 67.1. On average, LSA declined 10.1 points from pretreatment to 1 month and remained stable at 6 months. Pretreatment LSA score was associated with several demographic, clinical, geriatric assessment, and symptom characteristics. LSA decline at 1 month was greater among patients with high anxiety (slope = -12.6 vs. -2.3, p = 0.048). Pretreatment body mass index <21 kg/m
conclusionOlder adults with NSCLC have low pretreatment life space with many developing restricted life space during treatment. Incorporating life-space assessments into clinical cancer care may help older adults concretely visualize how treatment might impact their daily function to allow for informed decision making and identify early changes in mobility to implement supportive interventions.
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