Evidence map›Paper›PMID 34611842›Full record

SynthesisActa neurologica Belgica2022

Primary Sjögren's syndrome (pSS)-related cerebellar ataxia: a systematic review and meta-analysis.

Andreas Liampas, Antonios Nteveros, Konstantinos Parperis, Mohammed Akil, Efthymios Dardiotis, Elizabeth Andreadou, Marios Hadjivassiliou, Panagiotis Zis

Erratum issuedAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Acta neurologica Belgica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. MICA gene modulates immune microenvironment and comorbid mechanisms in diffuse large B-cell lymphoma and primary Sjögren's syndrome.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  3. Article
  4. Autoimmune Neurobeachin Cerebellar Ataxia.Movement disorders : official journal of the Movement Disorder Society · 2024
    Article
  5. Cerebellar ataxia and primary Sjogren's syndrome without cerebellar degeneration: a case report.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Andreas LiampasMedical School, University of Cyprus, Nicosia, Cyprus.
Antonios NteverosMedical School, University of Cyprus, Nicosia, Cyprus.
Konstantinos ParperisMedical School, University of Cyprus, Nicosia, Cyprus.
Mohammed AkilRheumatology Department, Sheffield Teaching Hospitals NHS Trust, Sheffield, UK.
Efthymios DardiotisDepartment of Neurology, Faculty of Medicine, School of Health Sciences, University of Thessaly, University Hospital of Larissa, Larissa, Greece.
Elizabeth AndreadouFirst Department of Neurology, National and Kapodistiran University of Athens, School of Medicine, "Eginition" University Hospital, Athens, Greece.
Marios HadjivassiliouAcademic Department of Neurosciences, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
Panagiotis ZisMedical School, University of Cyprus, Nicosia, Cyprus. takiszis@gmail.com.ORCID http://orcid.org/0000-0001-8567-3092
University of Cyprus · CYSheffield Teaching Hospitals NHS Foundation Trust · GBNational and Kapodistrian University of Athens · GRNicosia General Hospital · CYUniversity of Thessaly · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrimary Sjögren's syndrome (pSS) is a chronic autoimmune disorder characterized by lymphocytic infiltrates of the exocrine glands, particularly the salivary and lacrimal glands, resulting in oral and ocular dryness. pSS has been linked to various neurological manifestations, including cerebellar dysfunction. We aimed to provide a comprehensive analysis of the currently available evidence regarding pSS-related cerebellar ataxia.

methodsA systematic literature search in the PubMed database was performed and 19 papers were eligible to be included in this paper.

resultsThe pooled prevalence of cerebellar ataxia in pSS is estimated to be 1.5% (95% CI 0.3-6.8%). pSS patients with cerebellar involvement have a female-to-male ratio of 6:1. Although most of the patients are adults in their fifth decade of life when diagnosed, cases of children with pSS and cerebellar involvement have been reported. Typical cerebellar ataxia related to pSS manifests with vermian dysfunction, namely gait ataxia and/or cerebellar speech. Cerebellar ataxia due to pSS may also mimic degenerative cerebellar ataxia, especially when the onset is progressive.

conclusionsThe diagnostic approach to a patient with cerebellar ataxia of unknown etiology should include evaluation for an underlying pSS. A thorough history and clinical examination, antibody testing, brain MRI imaging and/or MRS of the cerebellum will assist in establishing the diagnosis. Setting up a joint neuro-rheumatology clinic can be valuable given that rheumatic and neurological diseases share comorbidities.

Indexed as

Cerebellar AtaxiaCerebellar DiseasesSjogren's SyndromeAdultChildFemaleHumansInflammationMagnetic Resonance ImagingMaleCerebellar ataxiaCerebellar syndromePrevalencePrimary Sjögren’sSyndrome (pSS)

Identifiers

PMID34611842
OpenAlexW3202853938

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.