Evidence map›Paper›PMID 34611826›Full record

ArticleTheory in biosciences = Theorie in den Biowissenschaften2021

Information transmission in a two-step cascade: interplay of activation and repression.

Tuhin Subhra Roy, Mintu Nandi, Ayan Biswas, Pinaki Chaudhury, Suman K Banik

Abstract read
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In one paragraph

Article in Theory in biosciences = Theorie in den Biowissenschaften, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tuhin Subhra RoyDepartment of Chemistry, Bose Institute, 93/1 A P C Road, Kolkata, 700009, India.
Mintu NandiDepartment of Chemistry, University of Calcutta, 92 A P C Road, Kolkata, 700009, India.
Ayan BiswasDepartment of Chemistry, Bose Institute, 93/1 A P C Road, Kolkata, 700009, India.
Pinaki ChaudhuryDepartment of Chemistry, University of Calcutta, 92 A P C Road, Kolkata, 700009, India.
Suman K BanikDepartment of Chemistry, Bose Institute, 93/1 A P C Road, Kolkata, 700009, India. skbanik@jcbose.ac.in.ORCID http://orcid.org/0000-0001-9369-6198

Funding

Council of Scientific and Industrial Research, India 09/015(0495)/2016-EMR-IUniversity Grants Commission 22/06/2014(i)EU-V
6 · The paper itself

Abstract

We present an information-theoretic formalism to study signal transduction in four architectural variants of a model two-step cascade with increasing input population. Our results categorize these four types into two classes depending upon the effect of activation and repression on mutual information, net synergy, and signal-to-noise ratio. Using the Gaussian framework and linear noise approximation, we derive the analytic expressions for these metrics to establish their underlying relationships in terms of the biochemical parameters. We also verify our approximations through stochastic simulations.

Indexed as

Signal TransductionStochastic ProcessesGene regulatory networkLinear noise approximationMutual informationPartial information decompositionSignal-to-noise ratioTwo-step cascade

Identifiers

PMID34611826

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.