Evidence map›Paper›PMID 34611794›Full record

ReviewCancer metastasis reviews2021

Updates and new directions in the use of radiation therapy for the treatment of pancreatic adenocarcinoma: dose, sensitization, and novel technology.

William A Hall, Mandana Kamgar, Beth A Erickson, Sara Beltrán Ponce, Susan Tsai, Marja T Nevalainen, Kathleen K Christians, Ben George, Kulwinder S Dua, Abdul H Khan and 2 more

Abstract readReview
In one paragraph

Review in Cancer metastasis reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

William A Hall *Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA. whall@mcw.edu.
Mandana Kamgar *Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.
Beth A EricksonDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
Sara Beltrán PonceDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
Susan TsaiDepartment of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.
Marja T NevalainenDepartment of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA.
Kathleen K ChristiansDepartment of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.
Ben GeorgeLaBahn Pancreatic Cancer Program at the Medical College of Wisconsin Cancer Center, Milwaukee, WI, USA.
Kulwinder S DuaLaBahn Pancreatic Cancer Program at the Medical College of Wisconsin Cancer Center, Milwaukee, WI, USA.
Abdul H KhanLaBahn Pancreatic Cancer Program at the Medical College of Wisconsin Cancer Center, Milwaukee, WI, USA.
Douglas B EvansDepartment of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.
Asfar S AzmiDepartment of Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA.

Funding

Institutional Career Development CoreKL2TR001438 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI WIDLANSKY, MICHAEL E · 2015 to 2024
$2.9M
Clinical Translation of Nuclear Export Inhibitor in Metastatic Pancreatic CancerR37CA215427 · NCI · WAYNE STATE UNIVERSITY · PI AZMI, ASFAR S · 2018 to 2024
$2.4M
A novel therapy for pancreatic neuroendocrine tumorsR01CA240607 · NCI · WAYNE STATE UNIVERSITY · PI AZMI, ASFAR S, EL-RAYES, BASSEL · 2020 to 2024
$1.7M
NCATS NIH HHS KL2 TR001438NCI NIH HHS R01 CA240607NCI NIH HHS R37 CA215427
6 · The paper itself

Abstract

Panc reatic ductal adenocarcinoma (PDAC) is a devastating malignancy. There have been few advances that have substantially improved overall survival in the past several years. On its current trajectory, the deaths from PDAC are expected to cross that from all gastrointestinal cancers combined by 2030. Radiation therapy is a technically very complex modality that bridges multiple different treatment strategies. It represents a hybrid among advanced diagnostic imaging, local (often ablative) intervention, and heterogeneous biological mechanisms contributing to normal and oncologic cell kill. In this article, we bring an overview of the several promising strategies that are currently being investigated to improve outcomes using radiation therapy for patients with PDAC.

Indexed as

AdenocarcinomaCarcinoma, Pancreatic DuctalPancreatic NeoplasmsHumansTechnologyAdvances in radiation for pancreatic cancerNovel RT techniquesPancreatic radiation therapyRadiation sensitization

Identifiers

PMID34611794
PMCPMC8767496

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.