ArticleInternational ophthalmology2022
Antibacterial effects of octadecyl trimethylammonium micelle-clay complex against bacterial eye pathogens: potential as a contact lens disinfectant.
Article in International ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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0 citing papers in PubMed, 3 citations in OpenAlex.
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Authors and funding
7 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
aimIn this study, we utilized a micelle-clay complex composed of the surfactant octadecyltrimethylammonium bromide and montmorillonite clay and evaluated its antibacterial effects.
methodsUsing Pseudomonas aeruginosa, Staphylococcus epidermidis, and Micrococcus luteus, bactericidal assays were performed to determine the effects of ODTMA-clay complex on the viability of bacterial pathogen at various doses and different intervals of time. Cytotoxicity assays were performed to investigate ODTMA-clay complex effects on human cells, as determined by release of intracellular lactate dehydrogenase.
resultsThe results revealed that ODTMA-clay complex abolished bacterial viability at 100 μg/mL within 45 min against P. aeruginosa, S. epidermidis, and M. luteus. Cytotoxicity assays revealed that ODTMA-clay complex exhibited minimal toxicity of the human cells.
conclusionRapid and potent antibacterial effects of ODTMA micelle-clay complex were observed in vitro; however, research is needed to determine precise formulation of contact lens disinfectants comprising ODTMA micelle-clay complex. Additionally, studies should be conducted using in vivo models of keratitis, progressing to pre-clinical and clinical trials. ODTMA micelle-clay complex is an ideal candidate to be incorporated in a novel contact lens disinfectant given the cost-effectiveness and ease of application and can be incorporated as an effective preventative strategy.
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