Evidence map›Paper›PMID 34611762›Full record

Observational studyChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2022

Postoperative hydrocephalus management may cause delays in adjuvant treatment following paediatric posterior fossa tumour resection: a multicentre retrospective observational study.

Ido Ben Zvi, Gideon Adegboyega, Sebastian M Toescu, Noa Schwartz, Amir Kershenovich, Helen Toledano, Shalom Michowiz, Kristian Aquilina

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. ETV for fourth ventricle outlet obstruction (FVOO) in the long-term period following pediatric posterior fossa tumor resection.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Article
  3. Article
  4. Molecular subgroup of medulloblastoma: evaluation of contribution to CSF diversion following tumour resection.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Ido Ben ZviDepartment of Neurosurgery, Great Ormond Street Hospital, London, UK. idobenz@gmail.com.ORCID 0000-0003-3700-0672
Gideon AdegboyegaThe London School of Medicine, Queen Mary University of London, London, UK.
Sebastian M ToescuDepartment of Neurosurgery, Great Ormond Street Hospital, London, UK.
Noa SchwartzDivision of Pediatric Neurosurgery, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.
Amir KershenovichDivision of Pediatric Neurosurgery, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.
Helen ToledanoHemato-Oncology Department, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.
Shalom MichowizDivision of Pediatric Neurosurgery, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.
Kristian AquilinaDepartment of Neurosurgery, Great Ormond Street Hospital, London, UK.
Great Ormond Street Hospital · GBSchneider Children's Medical Center · ILQueen Mary University of London · GBTel Aviv University · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHydrocephalus persists in 10-40% of children with posterior fossa tumours (PFT). A delay in commencement of adjuvant therapy (AT) can negatively influence survival. The objective of this study was to determine whether postoperative cerebrospinal fluid (CSF) diversion procedures caused potentially preventable delays in AT.

methodsA retrospective study of children diagnosed with PFT requiring AT from 2004 to 2018 from two large centres was conducted. Data on histology, timing of ventriculo-peritoneal shunt (VPS) insertion, and AT was collected. The modified Canadian Preoperative Prediction Rule for Hydrocephalus (mCPPRH) score was calculated. The primary outcome was delay in AT beyond 40 days post-resection. Progression-free and overall survival were assessed.

resultsOut of 196 primary PFT resections, 144 fitted the inclusion criteria. Mean age was 6.57 ± 4.62. Histology was medulloblastoma (104), ependymoma (27), and others (13). Forty patients had a VPS inserted; 17 of these experienced a delay in AT. A total of 104 patients were not shunted; 15 of these had delayed AT (p = 0.0007). Patients who had a VPS insertion had longer intervals from surgery to commencement of AT (34.5 vs 30.8, p = 0.05). There was no significant difference in mCPPRH score between those who had a VPS (4.03) and those who did not (3.61; p = 0.252). Multivariable linear regression modelling did not show a significant effect of VPS or mCPPRH on progression-free survival or OS.

conclusionCSF diversion procedures may cause a preventable delay in the initiation of adjuvant therapy. Early post-operative VP shunt insertion, rather than a 'wait and see policy' should be considered in order to reduce this delay.

Indexed as

Cerebellar NeoplasmsHydrocephalusInfratentorial NeoplasmsCanadaChildChild, PreschoolHumansInfantPostoperative ComplicationsRetrospective StudiesVentriculoperitoneal ShuntEpendymomaMedulloblastomaPredictive modelVentriculoperitoneal shunt

Identifiers

PMID34611762
OpenAlexW3202885928

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.