Evidence map›Paper›PMID 34611740›Full record

ArticleJournal of gastroenterology2021

A nationwide survey concerning the mortality and risk of progressing severity due to arterial and venous thromboembolism in inflammatory bowel disease in Japan.

Katsuyoshi Ando, Mikihiro Fujiya, Kenji Watanabe, Sakiko Hiraoka, Hisashi Shiga, Shinji Tanaka, Hideki Iijima, Tsunekazu Mizushima, Taku Kobayashi, Masakazu Nagahori and 24 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Cardiovascular manifestations of inflammatory bowel diseases and the underlying pathogenic mechanisms.American journal of physiology. Regulatory, integrative and comparative physiology · 2023
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 20 institutions in 1 country.

Katsuyoshi AndoGastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Gastroenterology, and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, 2-1 Midorigaoka-higashi, Asahikawa, Hokkaido, 078-8510, Japan.
Mikihiro FujiyaGastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Gastroenterology, and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, 2-1 Midorigaoka-higashi, Asahikawa, Hokkaido, 078-8510, Japan. fjym@asahikawa-med.ac.jp.ORCID 0000-0002-8641-8605
Kenji WatanabeCenter for Inflammatory Bowel Disease, Division of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan.
Sakiko HiraokaDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Hisashi ShigaDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Miyagi, Japan.
Shinji TanakaDepartment of Endoscopy and Medicine, Hiroshima University Hospital, Hiroshima, Japan.
Hideki IijimaDepartment of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka, Japan.
Tsunekazu MizushimaDepartment of Gastroenterological Surgery and Department of Therapeutics for Inflammatory Bowel Diseases, Graduate School of Medicine, Osaka University, Osaka, Japan.
Taku KobayashiCenter for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.
Masakazu NagahoriDepartment of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan.
Hiroki IkeuchiDepartment of Inflammatory Bowel Disease, Division of Surgery, Hyogo College of Medicine, Hyogo, Japan.
Shingo KatoDepartment of Gastroenterology and Hepatology, Saitama Medical Centre, Saitama Medical University, Saitama, Japan.
Takehiro TorisuDepartment of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kiyonori KobayashiResearch and Development Center for New Medical Frontiers, Kitasato University School of Medicine, Kanagawa, Japan.
Masaaki HigashiyamaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
Toshiro FukuiThe Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Osaka, Japan.
Takashi KagayaDepartments of Gastroenterology, National Hospital Organization Kanazawa Medical Center, Kanazawa, Japan.
Motohiro EsakiDivision of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan.
Shunichi YanaiDivision of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Iwate, Japan.
Daiki AbukawaDivision of General Pediatrics and Gastroenterology, Miyagi Children's Hospital, Miyagi, Japan.
Makoto NaganumaThe Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Osaka, Japan.
Satoshi MotoyaIBD Center, Hokkaido Prefectural Welfare Federation of Agricultural Cooperative, Sapporo-Kosei General Hospital, Hokkaido, Japan.
Masayuki SarutaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Shigeki BambaDivision of Digestive Endoscopy, Shiga University of Medical Science, Shiga, Japan.
Makoto SasakiDivision of Gastroenterology, Department of Internal Medicine, Aichi Medical University School of Medicine, Aichi, Japan.
Kazuhiko UchiyamaMolecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Katsuyuki FukudaDepartment of Gastroenterology, St Luke's International Hospital, Tokyo, Japan.
Hideo SuzukiDepartment of Gastroenterology, Graduate School of Institute Clinical Medicine, University of Tsukuba, Ibaraki, Japan.
Hiroshi NakaseDepartment of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Hokkaido, Japan.
Toshiaki ShimizuDepartment of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Masahiro IizukaHealth Care Center, Akita Red Cross Hospital, Akita, Japan.
Mamoru WatanabeInstitute of Innovation Advancement, Tokyo Medical and Dental University, Tokyo, Japan.
Yasuo SuzukiDepartment of Internal Medicine, Toho University Medical Center Sakura Hospital, Chiba, Japan.
Tadakazu HisamatsuDepartment of Gastroenterology and Hepatology, Kyorin University School of Medicine, Tokyo, Japan.
Asahikawa Medical University · JPHyogo Medical University · JPKansai Medical University · JPThe University of Osaka · JPTokyo Medical and Dental University · JPAichi Medical University · JPAkita Red Cross Hospital · JPHiroshima University Hospital · JPIwate Medical University · JPJikei University School of Medicine · JPJuntendo University · JPKanazawa Medical Center · JPKitasato Institute Hospital · JPKitasato University · JPKyorin University · JPKyoto Prefectural University of Medicine · JPKyushu University · JPMiyagi Children's Hospital · JPNational Defense Medical College · JPOkayama University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe mortality and risk factors of severe disease and death due to arterial and venous thromboembolism (ATE and VTE, respectively) in patients with inflammatory bowel disease (IBD) remain unclear, especially in Asia.

aimsThis study aimed to reveal the mortality and risk factors of TE in IBD patients in Japan.

methodsIn the primary surveillance, responses to questionnaires regarding the number of cases of severe TE and TE-associated death in IBD patients in a span of over the past 10 years were obtained from 32 institutions in Japan. In the secondary surveillance, detailed data about IBD patients with TE were collected. The characteristics, laboratory data, therapy status, and situation at the time of TE development were retrospectively collected, and the data were compared between the patients with and without severe TE and TE-associated death.

resultsThe incidence of TE was 1.89% among 31,940 IBD patients. The frequencies of severe TE and TE-associated mortality were 10.7% and 1.0% among the total IBD and TE with IBD patients, respectively. The only risk factor for severe ATE and ATE-associated death was ischemic heart disease. The independent risk factors for severe VTE and VTE-associated death were age (≤ 45 years old), the site of VTE, and disease severity, with anti-TNF therapy as a potential negative risk factor. Patients with severe VTE had a high risk of developing persistent VTE and sequelae.

conclusionUnlike ATE, the incidence of VTE was comparable in Asian and Western countries. Therapeutic and prophylactic strategies for managing IBD-associated TE in Asia are urgently needed.

Indexed as

Inflammatory Bowel DiseasesVenous ThromboembolismHumansJapanMiddle AgedRetrospective StudiesRisk FactorsSurveys and QuestionnairesTumor Necrosis Factor InhibitorsTumor Necrosis Factor InhibitorsArterial thromboembolismInflammatory bowel diseaseMortalitySeverityVenous thromboembolism

Identifiers

PMID34611740
PMCPMC8604847
OpenAlexW3203443626

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.