Evidence map›Paper›PMID 34611731›Full record

ArticleVirchows Archiv : an international journal of pathology2021

Vascular architectural patterns in clear cell renal cell carcinoma and clear cell papillary renal cell carcinoma.

Sofia Canete-Portillo, Maria Del Carmen Rodriguez Pena, Dezhi Wang, Diego F Sanchez, George J Netto, Cristina Magi-Galluzzi

Abstract read
PubMed Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. A multi-omics prognostic model and functional validation ofTranslational andrology and urology · 2026
    Article
  4. Article
  5. Imaging of abdominopelvic oncologic emergencies.Abdominal radiology (New York) · 2024
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sofia Canete-PortilloDepartment of Pathology, University of Alabama at Birmingham, NP 3545A, 1802 6th Avenue South, Birmingham, AL, 35249-7331, USA.
Maria Del Carmen Rodriguez PenaDepartment of Pathology, University of Alabama at Birmingham, NP 3545A, 1802 6th Avenue South, Birmingham, AL, 35249-7331, USA.
Dezhi WangDepartment of Pathology, University of Alabama at Birmingham, NP 3545A, 1802 6th Avenue South, Birmingham, AL, 35249-7331, USA.
Diego F SanchezInstituto de Patología E Investigación, Asunción, Paraguay.
George J NettoDepartment of Pathology, University of Alabama at Birmingham, NP 3545A, 1802 6th Avenue South, Birmingham, AL, 35249-7331, USA.
Cristina Magi-GalluzziDepartment of Pathology, University of Alabama at Birmingham, NP 3545A, 1802 6th Avenue South, Birmingham, AL, 35249-7331, USA. cmagigalluzzi@uabmc.edu.ORCID http://orcid.org/0000-0003-1219-3797

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal cell carcinomas (RCC) are well-vascularized tumors. Although clear cell RCC (CCRCC) show a characteristic vascular network, some cases show overlapping features with other RCC. We aimed to evaluate vascular architectural patterns, microvessel density (MVD), and endothelial cell density (ECD) in CCRCC compared to clear cell papillary RCC (ccpRCC). Thirty-four RCC (17 CCRCC and 17 ccpRCC) were included in the study. CD34 was used to evaluate vascular architectural patterns by microscopic estimation in all cases. CD34, ERG, and Bioquant Osteo 2019 Imaging Analysis Software were used to evaluate MVD and ECD in 17 CCRCC and 15 ccpRCC. Mean MVD was 526.63 in CCRCC vs. 426.18 in ccpRCC (p = 0.16); mean ECD was 937.50 in CCRCC vs. 1060.21 in ccpRCC (p = 0.25). CD34 highlighted four distinct vascular architectural patterns: pseudoacinar, Golgi-like, lacunae, and scattered. Lacunae and pseudoacinar was the most frequent combination in CCRCC; lacunae and Golgi-like was the predominant combination among ccpRCC. Pseudoacinar was most extensive in CCRCC and least in ccpRCC; Golgi-like was predominant in ccpRCC and uncommon in CCRCC. The extent of pseudoacinar and Golgi-like vascular architectural patterns was significantly different between CCRCC and ccpRCC (p < 0.05). Pathologists acquainted with these different vascular architectural patterns may utilize them as an additional tool in the distinction of CCRCC from ccpRCC.

Indexed as

Neovascularization, PathologicAdultAgedAged, 80 and overAntigens, CD34Biomarkers, TumorBiopsyBlood VesselsCarcinoma, Renal CellDiagnosis, DifferentialEndothelial CellsFemaleHumansImmunohistochemistryKidney NeoplasmsMaleAntigens, CD34Biomarkers, TumorCD34Clear cell papillary renal cell carcinomaClear cell renal cell carcinomaERGMicrovessel densityVascular architectural patterns

Identifiers

PMID34611731

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.