Evidence map›Paper›PMID 34611671›Full record

ArticlemedRxiv : the preprint server for health sciences2021

Pre-pandemic SARS-CoV-2 serological reactivity in rural malaria-experienced Cambodians.

Jessica Manning, Irfan Zaidi, Chanthap Lon, Luz Angela Rosas, Jae-Keun Park, Aiyana Ponce, Jennifer Bohl, Sophana Chea, Maria Karkanitsa, Sokunthea Sreng and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Jessica ManningNational Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Irfan ZaidiNational Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Chanthap LonNational Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Luz Angela RosasNational Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Jae-Keun ParkNational Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Aiyana PonceNational Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Jennifer BohlNational Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Sophana CheaNational Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia.
Maria Karkanitsa
Sokunthea SrengNational Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia.
Huy RekolNational Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia.
Char Meng ChourNational Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia.
Dominic EspositoFrederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Jeffery K TaubenbergerNational Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Matthew J MemoliNational Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Kaitlyn SadtlerNational Institute of Biomedical Imaging and Bioengineering, Bethesda, Maryland, USA.
Patrick E DuffyNational Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Fabiano OliveiraNational Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Greater Mekong inhabitants are exposed to pathogens, zoonotic and otherwise, that may influence SARS-CoV-2 seroreactivity. A pre-pandemic (2005 to 2011) serosurvey of from 528 malaria-experienced Cambodians demonstrated higher-than-expected (up to 13.8 %) positivity of non-neutralizing IgG to SARS-CoV-2 spike and RBD antigens. These findings have implications for interpreting large-scale serosurveys. ARTICLE SUMMARY LINE: In the pre-COVID19 pandemic years of 2005 to 2011, malaria experienced Cambodians from rural settings had higher-than-expected seroreactivity to SARS-CoV-2 spike and receptor binding domain proteins.

Identifiers

PMID34611671
PMCPMC8491862

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.