Evidence map›Paper›PMID 34611643›Full record

ArticleAmerican journal of preventive cardiology2021

The relationship between systemic inflammation and increased left ventricular mass is partly mediated by noncalcified coronary artery disease burden in psoriasis.

Wunan Zhou, Meron Teklu, Vy Bui, Grigory A Manyak, Promita Kapoor, Amit K Dey, Alexander V Sorokin, Nidhi Patel, Heather L Teague, Martin P Playford and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of preventive cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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  5. Two Alkaloids FromFrontiers in nutrition · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

Wunan ZhouNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Meron TekluNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Vy BuiNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Grigory A ManyakNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Promita KapoorNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Amit K DeyNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Alexander V SorokinNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Nidhi PatelNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Heather L TeagueNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Martin P PlayfordNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Julie Erb-AlvarezNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Justin A RodanteNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Andrew KeelNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Sujata M ShanbhagNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Li-Yueh HsuRadiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, United States.
David A BluemkeDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
Marcus Y ChenNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Marcus CarlssonNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Nehal N MehtaNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
National Heart Lung and Blood Institute · USNational Institutes of Health · USNational Institutes of Health Clinical Center · USUniversity of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIncreased left ventricular (LV) mass is an important precursor to heart failure. Inflammation plays an important role in increasing LV mass. However, the contribution of subclinical coronary artery disease (CAD) to the inflammation-LV mass relationship is unknown. In subjects with psoriasis, a chronic inflammatory skin disease, we evaluated if systemic inflammation assessed by plasma glycoprotein A (GlycA) associated with LV mass measured on coronary CT angiography (CCTA). Additionally, we analyzed whether this relationship was mediated by early CAD assessed as noncalcified coronary burden (NCB).

methodsWe performed an

resultsThe cohort had a mean age of 50.3 (±12.9) years and 59% were male. There was moderate psoriasis severity and low cardiovascular risk. LV mass increased by GlycA tertiles [1st tertile:24.6 g/m

conclusionsBoth systemic inflammation and coronary artery NCB were associated with LV mass beyond cardiovascular risk factors in psoriasis. Furthermore, a substantial proportion of the inflammatory-LV mass relationship was mediated by NCB. These findings underscore the possible contribution of early coronary artery disease to the relationship between systemic inflammation and LV mass.

Indexed as

Cardiac computed tomography angiographyCCTA, cardiac computed tomography angiographyGlycA, glycoprotein AHDL-C, high-density lipoprotein cholesterolhs-CRP, high sensitivity-C reactive proteinInflammationLDL-C, low- density lipoprotein cholesterolLeft ventricular massLV, left ventricularNCB, noncalcified coronary burdenNoncalcified coronary burden

Identifiers

PMID34611643
PMCPMC8387288
OpenAlexW3169188761

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.