ArticleOsteoarthritis and cartilage open2020
EFFECTS OF SOLUTE SIZE AND TISSUE COMPOSITION ON MOLECULAR AND MACROMOLECULAR DIFFUSIVITY IN HUMAN KNEE CARTILAGE.
Article in Osteoarthritis and cartilage open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 18 citations in OpenAlex.
- A Comparison of Cigarette Smoking Effects on Intervertebral Disc Cell Metabolism in a Rat Tissue Model.Annals of biomedical engineering · 2026Article
- Enhanced Diffusion and Retention of Proteoglycan Replacements in Cartilage through Thermoresponsive Polyelectrolytes.Macromolecules · 2025Article
- Atherosclerosis increases adventitial pressure and limits solute transport via fluid-balance mechanisms.Biomechanics and modeling in mechanobiology · 2025Article
- Solute transport from synovial fluid to articular cartilage and subchondral bone at different stages of osteoarthritis in a live mouse model.Journal of orthopaedic translation · 2025Article
- Human mesenchymal stem/stromal cell-derived extracellular vesicle transport in meniscus fibrocartilage.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Effect of cigarette smoke exposure and cessation on regional diffusion properties in rat intervertebral discs.JOR spine · 2024Article
- Functional Scaffolds for Bone Tissue Regeneration: A Comprehensive Review of Materials, Methods, and Future Directions.Journal of functional biomaterials · 2024Review
- Kinetics and Retention of Polystyrenesulfonate for Proteoglycan Replacement in Cartilage.Biomacromolecules · 2024Article
- Assessing the role of surface layer and molecular probe size in diffusion within meniscus tissue.PloS one · 2024Article
- Diffusivity of Human Cartilage Endplates in Healthy and Degenerated Intervertebral Disks.Journal of biomechanical engineering · 2023Article
- Effect of molecular weight and tissue layer on solute partitioning in the knee meniscus.Osteoarthritis and cartilage open · 2023Article
- [Study on transport of small molecule rhodamine B within different layers of cartilage].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2022Article
- Molecular Mechanisms of Cartilage Repair and Their Possible Clinical Uses: A Review of Recent Developments.International journal of molecular sciences · 2022Review
- Strain-Dependent Diffusivity of Small and Large Molecules in Meniscus.Journal of biomechanical engineering · 2022Article
- A bovine nucleus pulposus explant culture model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Application Effect of Different Concentrations of Platelet-Rich Plasma Combined with Quadriceps Training on Cartilage Repair of Knee Osteoarthritis.Journal of healthcare engineering · 2022Article
- Osteoarthritis-Related Degeneration Alters the Biomechanical Properties of Human Menisci Before the Articular Cartilage.Frontiers in bioengineering and biotechnology · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveArticular cartilage is an avascular tissue. Accordingly, diffusivity represents a fundamental transport mechanism for nutrients and other molecular signals regulating its cell metabolism and maintenance of the extracellular matrix. Understanding how solutes spread into articular cartilage is crucial to elucidating its pathologies, and to designing treatments for repair and restoration of its extracellular matrix. As in other connective tissues, diffusivity in articular cartilage may vary depending both its composition and the specific diffusing solute. Hence, this study investigated the roles of solute size and tissue composition on molecular diffusion in knee articular cartilage.
designFRAP tests were conducted to measure diffusivity of five molecular probes, with size ranging from ~332Da to 70,000Da, in human knee articular cartilage. The measured diffusion coefficients were related to molecular size, as well as water and glycosaminoglycan (GAG) content of femoral and tibial condyle cartilage.
resultsDiffusivity was affected by molecular size, with the magnitude of the diffusion coefficients decreasing as the Stokes radius of the probe increased. The values of diffusion coefficients in tibial and femoral samples were not significantly different from one another, despite the fact that tibial samples exhibited significantly higher water content and lower GAG content of the femoral specimens. Water content did not affect diffusivity. In contrast, diffusivities of large molecules were sensitive to GAG content.
conclusionsThis study provides new knowledge on the mechanisms of diffusion in articular cartilage. Our findings can be leveraged to further investigate osteoarthritis and to design treatments for cartilage restoration or replacement.
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