Evidence map›Paper›PMID 34611610›Full record

ArticleiScience2021

Postnatal prebiotic supplementation in rats affects adult anxious behaviour, hippocampus, electrophysiology, metabolomics, and gut microbiota.

Sonia O Spitzer, Andrzej Tkacz, Helene M Savignac, Matthew Cooper, Natasa Giallourou, Edward O Mann, David M Bannerman, Jonathan R Swann, Daniel C Anthony, Philip S Poole and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Sonia O SpitzerDepartment of Psychiatry, University of Oxford, Warneford Lane, Oxford, OX3 7JX, UK.
Andrzej TkaczDepartment of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, UK.
Helene M SavignacQuadram Institute, Rosalind Franklin Road, Norwich Research Park, Norwich NR4 7UQ, UK.
Matthew CooperDepartment of Physiology, Anatomy and Genomics, University of Oxford, Sherrington Building, Parks Road, Oxford OX1 3PT, UK.
Natasa GiallourouDepartment of Metabolism, Digestion and Reproduction, Imperial College, South Kensington Campus, London SW7 2AZ, UK.
Edward O MannDepartment of Physiology, Anatomy and Genomics, University of Oxford, Sherrington Building, Parks Road, Oxford OX1 3PT, UK.
David M BannermanOxford Ion Channel Initiative, University of Oxford, Oxford OX1 3PT, UK.
Jonathan R SwannDepartment of Metabolism, Digestion and Reproduction, Imperial College, South Kensington Campus, London SW7 2AZ, UK.
Daniel C AnthonyDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK.
Philip S PooleDepartment of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, UK.
Philip W J BurnetDepartment of Psychiatry, University of Oxford, Warneford Lane, Oxford, OX3 7JX, UK.
University of Oxford · GBImperial College London · GBNorwich Research Park · GBUniversity of Southampton · GB

Funding

Medical Research Council MR/N006321/1
6 · The paper itself

Abstract

We have shown previously that prebiotic (Bimuno galacto-oligosacharides, B-GOS®) administration to neonatal rats increased hippocampal NMDAR proteins. The present study has investigated the effects of postnatal B-GOS® supplementation on hippocampus-dependent behavior in young, adolescent, and adult rats and applied electrophysiological, metabolomic and metagenomic analyses to explore potential underlying mechanisms. The administration of B-GOS® to suckling, but not post-weaned, rats reduced anxious behavior until adulthood. Neonatal prebiotic intake also reduced the fast decay component of hippocampal NMDAR currents, altered age-specific trajectories of the brain, intestinal, and liver metabolomes, and reduced abundance of fecal

Indexed as

MicrobiologyMolecular physiologyNeuroscience

Identifiers

PMID34611610
PMCPMC8476651
OpenAlexW3197240746

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.