ArticleJOR spine2021
Structure-function relationships of the human vertebral endplate.
Article in JOR spine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Biomechanical, Structural, and Composition Characterization of the Vertebra-Disc Interface.JOR spine · 2026Article
- Article
- C- VBQ versus CT Hounsfield units in predicting cage subsidence following ACDF: a retrospective cohort analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Impact of endplate-graft geometric matching on cage subsidence following stand-alone lateral lumbar interbody fusion: a finite element analysis.BMC musculoskeletal disorders · 2026Article
- The I-PREDICT 50th Percentile Male Warfighter Finite Element Model: Development and Validation of the Head and Neck.Annals of biomedical engineering · 2026Article
- The I-PREDICT 50th Percentile Male Warfighter Finite Element Model: Development and Validation of the Thoracolumbar Spine.Annals of biomedical engineering · 2026Article
- Article
- Self-healing injectable multifunctional hydrogels for intervertebral disc disease.Materials today. Bio · 2025Review
- Risk of bony endplate failure during vertebral fracture.Journal of the mechanical behavior of biomedical materials · 2025Article
- Influence of disc height and strain-dependent solute diffusivity on metabolic transport in patient-personalized intervertebral disc models.Frontiers in bioengineering and biotechnology · 2025Article
- Stem cell-based strategies for intervertebral disc regeneration in degenerative microenvironments: challenges and solutions.Frontiers in cell and developmental biology · 2025Review
- The Role of Microvascular Variations in the Process of Intervertebral Disk Degeneration and Its Regulatory Mechanisms: A Literature Review.Orthopaedic surgery · 2024Review
- Progress in regulating inflammatory biomaterials for intervertebral disc regeneration.Bioactive materials · 2024Review
- A systematic morphology study on the effect of high glucose on intervertebral disc endplate degeneration in mice.Heliyon · 2023Article
- Genetics of Intervertebral Disc Degeneration.Current osteoporosis reports · 2023Review
- A Review of CT-Based Fracture Risk Assessment with Finite Element Modeling and Machine Learning.Current osteoporosis reports · 2022Review
- Regenerating and repairing degenerative intervertebral discs by regulating the micro/nano environment of degenerative bony endplates based on low-tension mechanics.BMC musculoskeletal disorders · 2022Article
- New Hope for Treating Intervertebral Disc Degeneration: Microsphere-Based Delivery System.Frontiers in bioengineering and biotechnology · 2022Review
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAlthough deformation and fracture of the vertebral endplate have been implicated in spinal conditions such as vertebral fracture and disc degeneration, few biomechanical studies of this structure are available. The goal of this study was to quantify the mechanical behavior of the vertebral endplate.
methodsEight-five rectangular specimens were dissected from the superior and/or inferior central endplates of human lumbar spine segments L1 to L4. Micro-computed tomography (μCT) imaging, four-point-bend testing, and ashing were performed to quantify the apparent elastic modulus and yield stress (modulus and yield stress, respectively, of the porous vertebral endplate), tissue yield stress (yield stress of the tissue of the vertebral endplate, excluding pores), ultimate strain, fracture strain, bone volume fraction (BV/TV), bone mineral density (BMD), and various measures of tissue density and composition (tissue mineral density, ash fraction, and ash density). Regression was used to assess the dependence of mechanical properties on density and composition.
resultsWide variations in elastic and failure properties, and in density and tissue composition, were observed. BMD and BV/TV were good predictors of many of the apparent-level mechanical properties, including modulus, yield stress, and in the case of the inferior vertebral endplate, failure strains. Similar values of the mechanical properties were noted between superior and inferior vertebral endplates. In contrast to the dependence of apparent stiffness and strength on BMD and BV/TV, none of the mechanical properties depended on any of the tissue-level density measurements.
conclusionThe dependence of many of the mechanical properties of the vertebral endplate on BV/TV and BMD suggests possibilities for noninvasive assessment of how this region of the spine behaves during habitual and injurious loading. Further study of the nonmineral components of the endplate tissue is required to understand how the composition of this tissue may influence the overall mechanical behavior of the vertebral endplate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.