ArticleJOR spine2021
Paraspinal muscle morphology and composition in adolescent idiopathic scoliosis: A histological analysis.
Article in JOR spine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Association between lean mass and adolescent idiopathic scoliosis: a meta-analysis.BMC musculoskeletal disorders · 2023Pooled it
- Impaired trunk sensorimotor control during isometric force reproduction involving rotation and extension in adolescents with idiopathic scoliosis.North American Spine Society journal · 2026Article
- Dynamic Infrared Thermography Reveals Bilateral Thermal Recovery Asymmetry in Scoliosis.Journal of clinical medicine · 2026Article
- Integrated transcriptomic and functional analysis reveals tissue-specific molecular pathology in adolescent idiopathic scoliosis.HGG advances · 2026Article
- Lumbar muscle morphology and composition in adolescent idiopathic scoliosis: a magnetic resonance study.Spine deformity · 2026Article
- Presynaptic Terminal Alterations in Concave and Convex Spinalis Muscles: A Pilot Exploratory Study in Advanced Scoliosis.Journal of clinical medicine · 2026Article
- CT-Derived Paraspinal Muscle Asymmetry Is Associated with Deformity Severity in Adolescent Idiopathic Scoliosis: A Quantitative CT Study.Journal of clinical medicine · 2026Article
- Oxygen dynamics in paraspinal muscles during isometric loading measured using near-infrared spectroscopy in adolescents with idiopathic scoliosis: SOSORT 2025 award winner.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- The role of proprioception in the management and rehabilitation of adolescent idiopathic scoliosis.Frontiers in rehabilitation sciences · 2026Article
- Multimodal quantitative characterization and mechanistic exploration of paraspinal muscle groups in adolescent idiopathic scoliosis.Frontiers in pediatrics · 2026Article
- Genome-wide association study identifiesPeerJ · 2026Article
- Asymmetrical paravertebral muscles fibrosis causes progression of adolescent idiopathic scoliosis via myostatin signalling in fibro-adipogenic progenitors.Journal of orthopaedic translation · 2026Article
- Integrating intrinsic musculoskeletal pathology and genetics: Recent advances in unravelling the causative factors of adolescent idiopathic scoliosis.Bone reports · 2025Review
- Beyond the Curve: The Muscle-Specific Asymmetries of Adolescent Idiopathic Scoliosis.JOR spine · 2025Article
- Trunk endurance differences between female adolescents with and without idiopathic scoliosis.Spine deformity · 2025Article
- Risk factors, lifestyle and prevention among adolescents with spinal curvature abnormality: a cross-sectional study in twenty-four primary and secondary schools in Hangzhou, Zhejiang Province, China.BMC public health · 2025Article
- The Neurogenic Abnormities of Paraspinal Muscles Lead to Asymmetry of Fibre Types in Adolescent Idiopathic Scoliosis.Journal of cellular and molecular medicine · 2025Article
- Paraspinal muscles activities in S-shaped adolescent idiopathic scoliosis during physiotherapeutic scoliosis specific exercise: a case-control study.BMC musculoskeletal disorders · 2025Article
- Putative epigenetic regulation mechanisms related to production, carcass and beef quality traits in Nelore cattle.Frontiers in genetics · 2025Article
- Comparison of elasticity changes in the paraspinal muscles of adolescent patients with scoliosis treated with surgery and bracing.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdolescent idiopathic scoliosis (AIS) is a condition resulting in spinal deformity and tissue adaptation of the paraspinal muscles. Although prior studies have demonstrated asymmetries in fiber type and other energetic features of muscle on the concave side of the curve, muscle morphology, architecture, and composition have not been evaluated. Therefore, the purpose of this study was to compare differences in paraspinal muscle microarchitecture and composition between concave and convex sides of a scoliotic curve in individuals with AIS.
methodsParaspinal muscle biopsies were obtained at the apex of the scoliotic curve in 29 individuals with AIS undergoing surgical deformity correction. Histological assays were performed to quantify fiber size, evidence of muscle degeneration and regeneration, and tissue composition (proportion of muscle, collagen, and fat). Differences between contralateral muscle samples were compared using two-tailed paired Student's
resultsMuscle fibers were significantly larger on the convex side of the curve apex (
conclusionsThis study demonstrates that although muscle fibers are larger on the convex side of the scoliotic curve in AIS, muscles on both sides are atrophic compared to non-scoliotic individuals, and demonstrate levels of collagen similar to severe degenerative spinal pathologies. These findings provide insight into biological maladaptations occurring in paraspinal muscle in the presence of AIS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.