Evidence map›Paper›PMID 34611512›Full record

ReviewIntegrative medicine research2021

Honeybee products for the treatment and recovery from viral respiratory infections including SARS-COV-2: A rapid systematic review.

Susan Arentz, Jennifer Hunter, Baljit Khamba, Michelle Mravunac, Zemirah Lee, Kristen Alexander, Romy Lauche, Joshua Goldenberg, Stephen P Myers

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Integrative medicine research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Susan ArentzNICM Health Research Institute, Western Sydney University, Sydney, NSW, Australia.
Jennifer HunterNICM Health Research Institute, Western Sydney University, Sydney, NSW, Australia.
Baljit KhambaBastyr University, San Diego, CA, USA.
Michelle MravunacTorrens University, Sydney, NSW, Australia.
Zemirah LeeBastyr University, San Diego, CA, USA.
Kristen AlexanderBastyr University, San Diego, CA, USA.
Romy LaucheNational Centre for Naturopathic Medicine, Faculty of Health, Southern Cross University, Lismore, NSW Australia.
Joshua GoldenbergHelfgott Research Institute, National University of Natural Medicine, Portland, OR & Seattle, WA, USA.
Stephen P MyersNICM Health Research Institute, Western Sydney University, Sydney, NSW, Australia.
Bastyr University · USWestern Sydney University · AUNational University of Natural Medicine · USSouthern Cross University · AUTorrens University Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis rapid review systematically evaluated the effects of honeybee products compared to controls for the prevention, duration, severity, and recovery of acute viral respiratory tract infections (RTIs), including SARS-CoV-2, in adults and children.

methodsCochrane rapid review methods were applied. Four English databases plus preprint servers and trial registries were searched for randomized controlled trials (RCTs). The evidence was appraised and synthesized using RoB 2.0 and GRADE.

results27 results were derived from 9 RCTs that included 674 adults and 781 children. In hospitalized adults with SARS-CoV-2, propolis plus usual-care compared to usual-care alone reduced the risk of shock, respiratory failure and kidney injury and duration of hospital admission. Honey was less effective than Guaifenesin for reducing cough severity at 60-minutes in adults with non-specific acute viral RTIs. Compared to coffee, honey plus coffee, and honey alone reduced the severity of post-infectious cough in adults. Honey reduced the duration of cough in children compared to placebo and salbutamol; and the global impact of nocturnal cough after one night compared to usual-care alone and pharmaceutical cough medicines.

conclusionMore studies are needed to robustly assess honeybee's role in SARS-CoV-2 and non-specific viral respiratory infections. PROTOCOL REGISTRATION: PROSPERO: CRD42020193847.

Indexed as

Complementary medicineCoronavirus pandemicCOVID-19Long-COVIDTCIM

Identifiers

PMID34611512
PMCPMC8483994
OpenAlexW3202345467

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.