Evidence map›Paper›PMID 34611431›Full record

ArticleInternational journal of general medicine2021

Molecular Mechanism of Sphingosine-1-Phosphate Receptor 1 Regulating CD4

Xiao-Xiao Yang, Chao Yang, Li Wang, Ying-Bo Zhou, Xiang Yuan, Nan Xiang, Yi-Ping Wang, Xiao-Mei Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of general medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Xiao-Xiao YangSchool of Life Sciences, University of Science and Technology of China, Hefei, Anhui, People's Republic of China.
Chao YangThe First Affiliated Hospital of USTC, Department of Rheumatology and Immunology, University of Science and Technology of China, Hefei, People's Republic of China.
Li WangThe First Affiliated Hospital of USTC, Department of Rheumatology and Immunology, University of Science and Technology of China, Hefei, People's Republic of China.ORCID 0000-0002-0486-7774
Ying-Bo ZhouThe First Affiliated Hospital of USTC, Department of Rheumatology and Immunology, University of Science and Technology of China, Hefei, People's Republic of China.
Xiang YuanThe First Affiliated Hospital of USTC, Department of Rheumatology and Immunology, University of Science and Technology of China, Hefei, People's Republic of China.
Nan XiangThe First Affiliated Hospital of USTC, Department of Rheumatology and Immunology, University of Science and Technology of China, Hefei, People's Republic of China.
Yi-Ping WangWestmead Institute for Medical Research, University of Sydney, Sdyney, NSW, 2145, Australia.
Xiao-Mei LiSchool of Life Sciences, University of Science and Technology of China, Hefei, Anhui, People's Republic of China.
University of Science and Technology of China · CNThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAlthough extensive research has been carried out on CD4

methodsLymphocyte infiltration in labial salivary glands (LSG) of pSS patients was detected by H&E staining. Expression of sphingosine-1-phosphate receptor 1 (S1PR1) in LSG was examined by Immunohistochemistry. Immunofluorescence analyses were utilized to detect the co-expression of CD4, CD69 and S1PR1 in T cells of LSG of pSS patients. Expression of gene

resultsS1PR1 was expressed in the infiltrating monocytes in LSG of pSS patients, and S1PR1 was weakly or even not expressed in cytoplasm of CD4

conclusionOur study suggests that the decrease of

Indexed as

CD4+TRMprimary Sjogren’s syndromeS1PR1

Identifiers

PMID34611431
PMCPMC8485922
OpenAlexW3204739319

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.