ArticleJournal of inflammation research2021
Circulating Inflammation Markers Partly Explain the Link Between the Dietary Inflammatory Index and Depressive Symptoms.
Article in Journal of inflammation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Serum Claudin-5 and Peripheral Inflammation in Major Depressive Disorder: A Case-Control Study with Focus on Suicidal Ideation.Alpha psychiatry · 2026Article
- The mediating role of the aggregate index of systemic inflammation between childhood emotional neglect and depressive severity in major depressive disorder: a cross-sectional study.Frontiers in psychiatry · 2026Article
- The moderating role of diet and physical activity in insulin resistance and immunometabolic depression.Scientific reports · 2025Article
- Dietary inflammatory index and its association with hematological inflammatory markers: a cross-sectional analysis in healthy and depressed individuals.BMC nutrition · 2025Article
- Association of Children's Dietary Inflammatory Index with Depression and Anxiety Symptoms in Adolescents: Mediating Role of Inflammation and Cardiometabolic Risk Factors.Alpha psychiatry · 2025Article
- Are Methylation Patterns in theInternational journal of molecular sciences · 2024Article
- Chronic Low-Grade Inflammation and Brain Structure in the Middle-Aged and Elderly Adults.Nutrients · 2024Article
- The association between dietary inflammation index and depression.Frontiers in psychiatry · 2023Article
- Cognitive Impairment Mediates the Association between Dietary Inflammation and Depressive Symptoms in the Elderly.Nutrients · 2022Article
- Empirical Dietary Inflammatory Pattern Scores Are Not Associated with Worse Cognitive Performance in the Nurses' Health Study.The Journal of nutrition · 2022Article
- Brain-Derived Neurotrophic Factor and Extracellular Vesicle-Derived miRNAs in an Italian Cohort of Individuals With Obesity: A Key to Explain the Link Between Depression and Atherothrombosis.Frontiers in cardiovascular medicine · 2022Article
- Role of leukocytes, gender, and symptom domains in the influence of depression on hospitalization and mortality risk: Findings from the Moli-sani study.Frontiers in psychiatry · 2022Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDepression is a mood disorder characterized by a high rate of resistance to pharmacological treatments, which has often been linked to chronic inflammation. This can be influenced by different environmental factors, in particular pro-inflammatory diets. However, a mediating role of circulating inflammation has never been observed.
aimTo test the association between a dietary inflammatory index (DII
resultsSignificant positive associations were observed between DII and total depressive symptoms (standardized β (SE) = 0.038 (0.005), p < 0.001), and with two factors tagging somatic (0.012 (0.003), p < 0.001) and cognitive symptoms (0.012 (0.003), p < 0.001), after adjustment for different potential confounders (socioeconomic status, chronic health conditions and lifestyles). These associations were about twice as strong in women than in men. INFLA-score explained a small but significant proportion of the association with total depressive symptoms (0.90-2.30%, p < 0.05), which was mainly driven by granulocyte-to-lymphocyte ratio (1.18-1.65%). This effect was even stronger for the somatic (2.66-4.66%) but not for the cognitive factor (0%).
conclusionThese findings support a strong link between inflammatory diet and depression, especially with somatic symptoms and within women. Moreover, they provide novel evidence for a potential explanatory role of circulating inflammation in this association, suggesting new paths for prevention and treatment of major and atypical depression.
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