Evidence map›Paper›PMID 34611414›Full record

ArticleInfection and drug resistance2021

Sulbactam Enhances in vitro Activity of β-Lactam Antibiotics Against

Leilei Wang, Yuancheng Chen, Renru Han, Zhiwei Huang, Xuefei Zhang, Fupin Hu, Fan Yang

Open access · goldAbstract read
In one paragraph

Article in Infection and drug resistance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Sulbactam-Durlobactam: A Novel Antibiotic Combination for the Treatment ofThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025
    Review
  4. Article
  5. Review
  6. Evaluation of the in vitro activity of ampicillin-sulbactam and cefoperazone-sulbactam against A. Baumannii by the broth disk elution test.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
    Article
  7. Sulbactam-durlobactam: A Step Forward in Treating Carbapenem-Resistant Acinetobacter baumannii (CRAB) Infections.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Growth kinetics of multipleF1000Research · 2022
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Leilei WangInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Yuancheng ChenInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Renru HanInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Zhiwei HuangInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Xuefei ZhangInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Fupin HuInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Fan YangInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Huashan Hospital · CNFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate in vitro activities of β-lactam antibiotics alone and in combination with sulbactam at different ratios against

methodsA total of 300 clinical isolates of

resultsHigh resistant rates for common antibiotics were observed except tigecycline and polymyxin B. Among carbapenem-resistant

conclusionThe increasing proportion of sulbactam could enhance antimicrobial activities of imipenem-sulbactam, ampicillin-sulbactam and cefoperazone-sulbactam combinations against

Indexed as

Acinetobacter baumanniiampicillincefoperazoneimipenemsulbactam

Identifiers

PMID34611414
PMCPMC8487265
OpenAlexW3202373386

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.