ArticleScientific reports2021
Right frontal anxiolytic-sensitive EEG 'theta' rhythm in the stop-signal task is a theory-based anxiety disorder biomarker.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed.
- Hope for Neurotic Disorders: A Summary of New Zealand Research on the Development of Biomarkers and Novel Treatments.Journal of the Royal Society of New Zealand · 2026Article
- A four-factor model of psychopathy assessed via neural reinforcement sensitivity theory.Personality neuroscience · 2026Article
- Sleep disorder increases risk of psychiatric disorder in burn survivors.Burns : journal of the International Society for Burn Injuries · 2025Article
- Trait anxiety is associated with reduced reward-related replay at rest.Nature communications · 2025Article
- Comparison of overnight trends in relative power for specific frequency bands, sleep stages, and brain regions between patients with depressive disorder and matched control subjects.Psychiatry research. Neuroimaging · 2025Article
- The power spectrum and functional connectivity characteristics of resting-state EEG in patients with generalized anxiety disorder.Scientific reports · 2025Article
- Perspective: Hippocampal theta rhythm as a potential vestibuloacoustic biomarker of anxiety.The European journal of neuroscience · 2025Review
- Rhythmic activity in resting-state EEG predicts trait anxiety.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Risk avoidance and social anxiety in adolescence: Examination of event-related potentials and theta-dynamics on the Balloon Risk Avoidance Task.Brain and cognition · 2024Article
- Is lack of goal-conflict-specific rhythmicity a biomarker for treatment resistance in generalised anxiety but not social anxiety or major depression?Journal of psychopharmacology (Oxford, England) · 2024Article
- Midfrontal conflict theta and parietal P300 are linked to a latent factor of DSM externalising disorders.Personality neuroscience · 2024Article
- Midfrontal theta reactivity to conflict and error are linked to externalizing and internalizing respectively.Personality neuroscience · 2024Article
- Developmental trajectories of sensitivity to threat in children and adolescents predict larger medial frontal theta differentiation during response inhibition.Social cognitive and affective neuroscience · 2023Article
- Anterior cingulate and medial prefrontal cortex oscillations underlie learning alterations in trait anxiety in humans.Communications biology · 2023Article
- Analysis of Meditation vs. Sensory Engaged Brain States Using Shannon Entropy and Pearson's First Skewness Coefficient Extracted from EEG Data.Sensors (Basel, Switzerland) · 2023Article
- Identification of spatial patterns with maximum association between power of resting state neural oscillations and trait anxiety.Neural computing & applications · 2023Article
- Associations between Heart Rate Variability and Brain Activity during a Working Memory Task: A Preliminary Electroencephalogram Study on Depression and Anxiety Disorder.Brain sciences · 2022Article
- Theta oscillations: A rhythm difference comparison between major depressive disorder and anxiety disorder.Frontiers in psychiatry · 2022Article
- Neuropsychological Theory as a Basis for Clinical Translation of Animal Models of Neuropsychiatric Disorder.Frontiers in behavioral neuroscience · 2022Article
- Non-human contributions to personality neuroscience - from fish through primates. An introduction to the special issue.Personality neuroscience · 2022Review
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8 authors.
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Abstract
Psychiatric diagnoses currently rely on a patient's presenting symptoms or signs, lacking much-needed theory-based biomarkers. Our neuropsychological theory of anxiety, recently supported by human imaging, is founded on a longstanding, reliable, rodent 'theta' brain rhythm model of human clinical anxiolytic drug action. We have now developed a human scalp EEG homolog-goal-conflict-specific rhythmicity (GCSR), i.e., EEG rhythmicity specific to a balanced conflict between goals (e.g., approach-avoidance). Critically, GCSR is consistently reduced by different classes of anxiolytic drug and correlates with clinically-relevant trait anxiety scores (STAI-T). Here we show elevated GCSR in student volunteers divided, after testing, on their STAI-T scores into low, medium, and high (typical of clinical anxiety) groups. We then tested anxiety disorder patients (meeting diagnostic criteria) and similar controls recruited separately from the community. The patient group had higher average GCSR than their controls-with a mixture of high and low GCSR that varied with, but cut across, conventional disorder diagnosis. Consequently, GCSR scores should provide the first theoretically-based biomarker that could help diagnose, and so redefine, a psychiatric disorder.
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