ArticleScientific reports2021
Differentiating coronavirus disease 2019 (COVID-19) from influenza and dengue.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 38 citations in OpenAlex.
- Kelleni's protocol incorporating non-steroidal anti-inflammatory drugs and nitazoxanide to early manage dengue virus disease: An antiviral silver bullet.World journal of clinical cases · 2025Review
- Association between influenza vaccine effectiveness and chronic diseases among older adults with dementia.Scientific reports · 2025Article
- Dengue Mimickers: Which Clinical Conditions Can Resemble Dengue Fever?Revista da Sociedade Brasileira de Medicina Tropical · 2024Review
- Evaluation of the Diagnostic Performance of a SARS-CoV-2 and Influenza A/B Combo Rapid Antigen Test in Respiratory Samples.Diagnostics (Basel, Switzerland) · 2023Article
- Distinguishing SARS-CoV-2 Infection and Non-SARS-CoV-2 Viral Infections in Adult Patients through Clinical Score Tools.Tropical medicine and infectious disease · 2023Article
- Clinical Features of COVID-19, Dengue, and Influenza among Adults Presenting to Emergency Departments and Urgent Care Clinics-Puerto Rico, 2012-2021.The American journal of tropical medicine and hygiene · 2023Article
- Article
- A prospective evaluation of diagnostic performance of a combo rapid antigen test QuickNavi-Flu+COVID19 Ag.Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2022Article
- Dengue and COVID-19: Managing Undifferentiated Febrile Illness during a "Twindemic".Tropical medicine and infectious disease · 2022Article
- Coinfection and cross-reaction of dengue and COVID-19: a case series analysis.Revista da Sociedade Brasileira de Medicina Tropical · 2022Article
- Pulmonary hemorrhage in dengue: differential diagnosis with acute viral respiratory syndromes including COVID-19.Revista do Instituto de Medicina Tropical de Sao Paulo · 2022Article
- Comprehensive Flow Cytometry Profiling of the Immune System in COVID-19 Convalescent Individuals.Frontiers in immunology · 2021Article
- Differentiating COVID-19 and dengue from other febrile illnesses in co-epidemics: Development and internal validation of COVIDENGUE scores.Travel medicine and infectious diseaseArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The novel coronavirus disease 2019 (COVID-19) presents with non-specific clinical features. This may result in misdiagnosis or delayed diagnosis, and lead to further transmission in the community. We aimed to derive early predictors to differentiate COVID-19 from influenza and dengue. The study comprised 126 patients with COVID-19, 171 with influenza and 180 with dengue, who presented within 5 days of symptom onset. All cases were confirmed by reverse transcriptase polymerase chain reaction tests. We used logistic regression models to identify demographics, clinical characteristics and laboratory markers in classifying COVID-19 versus influenza, and COVID-19 versus dengue. The performance of each model was evaluated using receiver operating characteristic (ROC) curves. Shortness of breath was the strongest predictor in the models for differentiating between COVID-19 and influenza, followed by diarrhoea. Higher lymphocyte count was predictive of COVID-19 versus influenza and versus dengue. In the model for differentiating between COVID-19 and dengue, patients with cough and higher platelet count were at increased odds of COVID-19, while headache, joint pain, skin rash and vomiting/nausea were indicative of dengue. The cross-validated area under the ROC curve for all four models was above 0.85. Clinical features and simple laboratory markers for differentiating COVID-19 from influenza and dengue are identified in this study which can be used by primary care physicians in resource limited settings to determine if further investigations or referrals would be required.
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