Evidence map›Paper›PMID 34611194›Full record

ArticleScientific reports2021

NEIL3-deficiency increases gut permeability and contributes to a pro-atherogenic metabolic phenotype.

Tom Rune Karlsen, Xiang Yi Kong, Sverre Holm, Ana Quiles-Jiménez, Tuva B Dahl, Kuan Yang, Ellen L Sagen, Tonje Skarpengland, Jonas D S Øgaard, Kristian Holm and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Omics research in atherosclerosis.Molecular and cellular biochemistry · 2025
    Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Tom Rune KarlsenResearch Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway. t.r.karlsen@medisin.uio.no.
Xiang Yi KongResearch Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Sverre HolmResearch Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Ana Quiles-JiménezResearch Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Tuva B DahlResearch Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Kuan YangResearch Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Ellen L SagenResearch Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Tonje SkarpenglandResearch Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Jonas D S ØgaardResearch Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Kristian HolmResearch Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Beate VestadResearch Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Maria B OlsenResearch Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Pål AukrustResearch Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Magnar BjøråsDepartment of Microbiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Johannes R HovResearch Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Bente HalvorsenResearch Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway. b.e.halvorsen@medisin.uio.no.
Ida GregersenResearch Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway. ida.gregersen@medisin.uio.no.
Oslo University Hospital · NOUniversity of Oslo · NONorwegian University of Science and Technology · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis and its consequences cause considerable morbidity and mortality world-wide. We have previously shown that expression of the DNA glycosylase NEIL3 is regulated in human atherosclerotic plaques, and that NEIL3-deficiency enhances atherogenesis in Apoe

Indexed as

Energy MetabolismAge FactorsAnimalsAtherosclerosisBiomarkersDisease Models, AnimalDisease SusceptibilityDysbiosisGastrointestinal MicrobiomeGenetic Predisposition to DiseaseHumansImmunohistochemistryIntestinal MucosaMiceMice, KnockoutN-Glycosyl HydrolasesBiomarkersNEIL3 protein, humanN-Glycosyl Hydrolases

Identifiers

PMID34611194
PMCPMC8492623
OpenAlexW3204790832

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.