Evidence map›Paper›PMID 34611166›Full record

ArticleNature communications2021

Antigen presentation by lung epithelial cells directs CD4

Anukul T Shenoy, Carolina Lyon De Ana, Emad I Arafa, Isabelle Salwig, Kimberly A Barker, Filiz T Korkmaz, Aditya Ramanujan, Neelou S Etesami, Alicia M Soucy, Ian M C Martin and 9 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 124 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. CIITA/PRMT5 promote CD4BMC medicine · 2026
    Article
  9. PD-1 Inhibits CD4+ TRM-Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  10. Review
  11. Article
  12. Article
  13. HIF-1αImmunity · 2026
    Article
  14. When Checkpoint Inhibitors Break Barriers: Mechanisms and Challenges of irAEs of the Skin, Gastrointestinal Tract, and Lung.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Review
  15. Article
  16. Review
  17. Oesophageal Epithelial Cell-Intrinsic MHCII Regulates Food Antigen-Dependent Eosinophilic Esophagitis in an IFNγ-Dependent Manner.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026
    Article
  18. Review
  19. Article
  20. Article

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 2 countries.

Anukul T ShenoyPulmonary Center, Boston University School of Medicine, Boston, MA, 02118, USA.ORCID 0000-0001-8861-2295
Carolina Lyon De AnaPulmonary Center, Boston University School of Medicine, Boston, MA, 02118, USA.ORCID 0000-0002-2964-1624
Emad I ArafaPulmonary Center, Boston University School of Medicine, Boston, MA, 02118, USA.
Isabelle SalwigDepartment of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany.
Kimberly A BarkerPulmonary Center, Boston University School of Medicine, Boston, MA, 02118, USA.
Filiz T KorkmazPulmonary Center, Boston University School of Medicine, Boston, MA, 02118, USA.
Aditya RamanujanPulmonary Center, Boston University School of Medicine, Boston, MA, 02118, USA.ORCID 0000-0003-2055-6826
Neelou S EtesamiPulmonary Center, Boston University School of Medicine, Boston, MA, 02118, USA.ORCID 0000-0002-6725-2646
Alicia M SoucyPulmonary Center, Boston University School of Medicine, Boston, MA, 02118, USA.ORCID 0000-0002-2636-7703
Ian M C MartinPulmonary Center, Boston University School of Medicine, Boston, MA, 02118, USA.
Brian R TiltonFlow Cytometry Core Facility, Boston University School of Medicine, Boston, MA, 02118, USA.
Anne HindsPulmonary Center, Boston University School of Medicine, Boston, MA, 02118, USA.
Wesley N GoltryPulmonary Center, Boston University School of Medicine, Boston, MA, 02118, USA.
Hasmeena KathuriaPulmonary Center, Boston University School of Medicine, Boston, MA, 02118, USA.
Thomas BraunDepartment of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany.ORCID 0000-0002-6165-4804
Matthew R JonesPulmonary Center, Boston University School of Medicine, Boston, MA, 02118, USA.
Lee J QuintonPulmonary Center, Boston University School of Medicine, Boston, MA, 02118, USA.ORCID 0000-0003-1938-2507
Anna C BelkinaPulmonary Center, Boston University School of Medicine, Boston, MA, 02118, USA.ORCID 0000-0001-7967-6254
Joseph P MizgerdPulmonary Center, Boston University School of Medicine, Boston, MA, 02118, USA. jmizgerd@bu.edu.ORCID 0000-0002-4042-3169
Boston University · USMax Planck Institute for Heart and Lung Research · DE

Funding

BIOLOGY OF THE LUNG--MULTIDISCIPLINARY PROGRAMT32HL007035 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Darrell N. Kotton, JOSEPH P MIZGERD · 1985 to 2026
$24.3M
Pneumonia BiologyR35HL135756 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MIZGERD, JOSEPH P · 2017 to 2023
$6.6M
Lung-resident antibacterial heterotypic immunityR01AI115053 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MIZGERD, JOSEPH P · 2015 to 2023
$4.0M
The Biology of LIF During PneumoniaR01HL111449 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI QUINTON, LEE · 2012 to 2020
$3.7M
The B cell repertoire as a window into the nature and impact of the lung viromeR33HL137081 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FEARNS, RACHEL, KEPLER, THOMAS B · 2019 to 2021
$2.4M
Origins and functional roles of Miwi2-positive multiciliated cells during inflammationR01HL136725 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FINE, ALAN FINE, JONES, MATTHEW ROBERT · 2018 to 2021
$1.6M
Liver-derived protection during pneumonia and sepsisR01GM120060 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI QUINTON, LEE · 2017 to 2020
$1.3M
The B cell repertoire as a window into the nature and impact of the lung viromeR61HL137081 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FEARNS, RACHEL, KEPLER, THOMAS B · 2017 to 2018
$565k
The role of Lox-1 during pneumoniaF32HL147461 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KORKMAZ, FILIZ · 2019 to 2020
$127k
Lung Memory B Cell Contributions to Heterotypic Anti-Pneumococcal ImmunityF31HL142199 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BARKER, KIMBERLY ALYNN · 2018 to 2020
$110k
Pneumonia and Alveolar Macrophage ResilienceF31HL147397 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ARAFA, EMAD · 2019 to 2021
$93k
NHLBI NIH HHS F31 HL142199NHLBI NIH HHS F31 HL147397NHLBI NIH HHS F32 HL147461NHLBI NIH HHS R01 HL111449NHLBI NIH HHS R01 HL136725NHLBI NIH HHS R33 HL137081NHLBI NIH HHS R35 HL135756NHLBI NIH HHS R61 HL137081NHLBI NIH HHS T32 HL007035NIAID NIH HHS R01 AI115053NIGMS NIH HHS R01 GM120060
6 · The paper itself

Abstract

Barrier tissues are populated by functionally plastic CD4

Indexed as

AnimalsAntigen PresentationCD4-Positive T-LymphocytesEpithelial CellsFlow CytometryFluorescent Antibody TechniqueLeukocytesLungMiceMice, Inbred C57BLMicroscopy, Electron, TransmissionReal-Time Polymerase Chain Reaction

Identifiers

PMID34611166
PMCPMC8492657
OpenAlexW3202164430

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.