Evidence map›Paper›PMID 34611130›Full record

ArticleCell death & disease2021

The spliceosome factor sart3 regulates hematopoietic stem/progenitor cell development in zebrafish through the p53 pathway.

Yan Zhao, Mei Wu, Jing Li, Ping Meng, Jiakui Chen, Zhibin Huang, Jin Xu, Zilong Wen, Wenqing Zhang, Yiyue Zhang

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. The role of p53 in male infertility.Frontiers in endocrinology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Yan Zhao *Division of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology, Guangzhou, 510006, P.R. China.ORCID 0000-0001-8635-6443
Mei Wu *Division of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology, Guangzhou, 510006, P.R. China.ORCID 0000-0002-6021-6554
Jing LiDivision of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology, Guangzhou, 510006, P.R. China.
Ping MengDepartment of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, P.R. China.
Jiakui ChenDepartment of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, P.R. China.
Zhibin HuangDivision of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology, Guangzhou, 510006, P.R. China.
Jin XuDivision of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology, Guangzhou, 510006, P.R. China.ORCID 0000-0002-6840-1359
Zilong WenState Key Laboratory of Molecular Neuroscience, Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, P.R. China.
Wenqing ZhangDivision of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology, Guangzhou, 510006, P.R. China. mczhangwq@scut.edu.cn.ORCID 0000-0002-3636-7133
Yiyue ZhangDivision of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology, Guangzhou, 510006, P.R. China. mczhangyy@scut.edu.cn.ORCID 0000-0002-9402-3523
South China University of Technology · CNSouthern Medical University · CNHong Kong University of Science and Technology · HK

Funding

National Natural Science Foundation of China (National Science Foundation of China) 31922023
6 · The paper itself

Abstract

Hematopoietic stem cells (HSCs) possess the potential for self-renew and the capacity, throughout life, to differentiate into all blood cell lineages. Yet, the mechanistic basis for HSC development remains largely unknown. In this study, we characterized a zebrafish smu471 mutant with hematopoietic stem/progenitor cell (HSPC) defects and found that sart3 was the causative gene. RNA expression profiling of the sart3

Indexed as

Signal TransductionAlternative SplicingAnimalsApoptosisBase SequenceCell ProliferationDEAD-box RNA HelicasesHematopoietic Stem CellsModels, BiologicalMutationRNA Splicing FactorsSpliceosomesTumor Suppressor Protein p53ZebrafishZebrafish ProteinsDEAD-box RNA HelicasesMdm4 protein, zebrafishRNA Splicing FactorsSART3 protein, zebrafishTumor Suppressor Protein p53Zebrafish Proteins

Identifiers

PMID34611130
PMCPMC8492694
OpenAlexW3203748286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.