ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Developmental Shifts in Amygdala Activity during a High Social Drive State.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- A Dose-Finding, Biomarker Validation, and Effectiveness Study of Transcranial Magnetic Stimulation for Adolescents With Depression.Journal of the American Academy of Child and Adolescent Psychiatry · 2025Trial
- Postnatal maturation of the basolateral and paralaminar amygdala in rodents: implications for social-emotional development.Frontiers in neuroscience · 2026Review
- The Amygdala Regulates Social Motivation for Selective Vocal Imitation in Zebra Finches.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Juvenile social isolation in Sprague Dawley rats does not have a lasting impact on social behavior in adulthood.Scientific reports · 2025Article
- Age- and cytokine-dependent modulation of GABAergic transmission within the basolateral amygdala of male Sprague Dawley rats.Neuropharmacology · 2025Article
- Enhanced social motivation in briefly isolated male rats.IBRO neuroscience reports · 2023Article
- Stress, associative learning, and decision-making.Neurobiology of learning and memory · 2023Review
- Maturation of a cortical-amygdala circuit limits sociability in male rats.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Amygdala circuit transitions supporting developmentally-appropriate social behavior.Neurobiology of learning and memory · 2023Review
- Liposaccharide-induced sustained mild inflammation fragments social behavior and alters basolateral amygdala activity.Psychopharmacology · 2023Article
- Isolation driven changes in Iba1-positive microglial morphology are associated with social recognition memory in adults and adolescents.Neurobiology of learning and memory · 2022Article
- Developmental differences in amygdala projection neuron activation associated with isolation-driven changes in social preference.Frontiers in behavioral neuroscience · 2022Article
- The Changes of Amygdala Transcriptome in Autism Rat Model After Arginine Vasopressin Treatment.Frontiers in neuroscience · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Amygdala abnormalities characterize several psychiatric disorders with prominent social deficits and often emerge during adolescence. The basolateral amygdala (BLA) bidirectionally modulates social behavior and has increased sensitivity during adolescence. We tested how an environmentally-driven social state is regulated by the BLA in adults and adolescent male rats. We found that a high social drive state caused by brief social isolation increases age-specific social behaviors and increased BLA neuronal activity. Chemogenetic inactivation of BLA decreased the effect of high social drive on social engagement. High social drive preferentially enhanced BLA activity during social engagement; however, the effect of social opportunity on BLA activity was greater during adolescence. While this identifies a substrate underlying age differences in social drive, we then determined that high social drive increased BLA NMDA GluN2B expression and sensitivity to antagonism increased with age. Further, the effect of a high social drive state on BLA activity during social engagement was diminished by GluN2B blockade in an age-dependent manner. These results demonstrate the necessity of the BLA for environmentally driven social behavior, its sensitivity to social opportunity, and uncover a maturing role for BLA and its GluN2B receptors in social engagement.
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