Evidence map›Paper›PMID 34610905›Full record

ArticleBMJ global health2021

Engaging with the private healthcare sector for the control of tuberculosis in India: cost and cost-effectiveness.

Nimalan Arinaminpathy, Arindam Nandi, Shibu Vijayan, Nita Jha, Sreenivas A Nair, Sameer Kumta, Puneet Dewan, Kiran Rade, Bhavin Vadera, Raghuram Rao and 1 more

Open access · goldAbstract read
In one paragraph

Article in BMJ global health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Private sector engagement in tuberculosis detection: a bibliometric analysis.Journal of clinical tuberculosis and other mycobacterial diseases · 2026
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  16. Implementation of a tuberculosis elimination project, India 2018-2019.Bulletin of the World Health Organization · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Nimalan ArinaminpathyDepartment of Infectious Disease Epidemiology, Imperial College London, London, London, UK nim.pathy@imperial.ac.uk.ORCID 0000-0001-9502-6876
Arindam NandiPopulation Council, New York, New York, USA.ORCID 0000-0002-3967-2424
Shibu VijayanPATH Mumbai Office, Mumbai, India.
Nita JhaWorld Health Partners, Patna, India.
Sreenivas A NairStop TB Partnership, Geneva, Switzerland.
Sameer KumtaBill and Melinda Gates Foundation, India Country Office, New Delhi, India.
Puneet DewanBill and Melinda Gates Foundation, Seattle, Washington, USA.
Kiran RadeWorld Health Organization Country Office for India, New Delhi, India.
Bhavin VaderaUSAID India, New Delhi, India.
Raghuram RaoNational Tuberculosis Elimination Programme, India Ministry of Health and Family Welfare, New Delhi, India.
Kuldeep S SachdevaSouth-East Asia Office, International Union Against Tuberculosis and Lung Disease, New Delhi, India.
Center for Disease Dynamics, Economics & Policy · USGates Foundation · USImperial College London · GBMinistry of Health and Family Welfare · INWorld Health Organization - India · INWorld Health Partners · IN

Funding

Medical Research Council MR/R015600/1World Health Organization 001
6 · The paper itself

Abstract

backgroundThe control of tuberculosis (TB) in India is complicated by the presence of a large, disorganised private sector where most patients first seek care. Following pilots in Mumbai and Patna (two major cities in India), an initiative known as the 'Public-Private Interface Agency' (PPIA) is now being expanded across the country. We aimed to estimate the cost-effectiveness of scaling up PPIA operations, in line with India's National Strategic Plan for TB control.

methodsFocusing on Mumbai and Patna, we collected cost data from implementing organisations in both cities and combined this data with models of TB transmission dynamics. Estimating the cost per disability adjusted life years (DALY) averted between 2014 (the start of PPIA scale-up) and 2025, we assessed cost-effectiveness using two willingness-to-pay approaches: a WHO-CHOICE threshold based on per-capita economic productivity, and a more stringent threshold incorporating opportunity costs in the health system.

findingsA PPIA scaled up to ultimately reach 50% of privately treated TB patients in Mumbai and Patna would cost, respectively, US$228 (95% uncertainty interval (UI): 159 to 320) per DALY averted and US$564 (95% uncertainty interval (UI): 409 to 775) per DALY averted. In Mumbai, the PPIA would be cost-effective relative to all thresholds considered. In Patna, if focusing on adherence support, rather than on improved diagnosis, the PPIA would be cost-effective relative to all thresholds considered. These differences between sites arise from variations in the burden of drug resistance: among the services of a PPIA, improved diagnosis (including rapid tests with genotypic drug sensitivity testing) has greatest value in settings such as Mumbai, with a high burden of drug-resistant TB.

conclusionsTo accelerate decline in TB incidence, it is critical first to engage effectively with the private sector in India. Mechanisms such as the PPIA offer cost-effective ways of doing so, particularly when tailored to local settings.

Indexed as

Private SectorTuberculosisCost-Benefit AnalysisHealth Care SectorHumansIndiahealth economicstuberculosis

Identifiers

PMID34610905
PMCPMC8493898
OpenAlexW3203758200

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.