ArticleBMC oral health2021
Polymorphic variants in genes related to stress coping are associated with the awake bruxism.
Article in BMC oral health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- The Relation Between Daytime Sleepiness and Awake and Sleep Bruxism Report in Patients With Obstructive Sleep Apnoea.Journal of oral rehabilitation · 2025Article
- Sleep Bruxism Self-Report and Awake Bruxism: An Ecological Momentary Assessment.Oral diseases · 2025Article
- Family history of bruxism: a case-control study based on the ecological momentary assessment of awake bruxism.Journal of oral & facial pain and headache · 2025Article
- Parent-perceived oral habits among a group of school children: prevalence and predictors.BDJ open · 2024Article
- Clenching the Strings of Bruxism Etiopathogenesis: Association Analyses on Genetics and Environmental Risk Factors in a Deeply Characterized Italian Cohort.Biomedicines · 2024Article
- The neural substrates of bruxism: current knowledge and clinical implications.Frontiers in neurology · 2024Review
- The association of self-reported awake bruxism and sleep bruxism with temporomandibular pain and dysfunction in adult patients with temporomandibular disorders.Clinical oral investigations · 2023Article
- The association between sleep bruxism and awake bruxism: Polysomnographic and electromyographic recordings in women with and without myofascial pain.Journal of oral rehabilitation · 2023Article
- Altered Plasma Proteins in Myogenous Temporomandibular Disorders.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic stress is one of the leading predisposing factors in bruxism aetiology, but the influence of genetic factors is also suggested. We aimed to study whether sequence variants in genes involved in stress regulation pathways: NTRK2 and BDNF, may be associated with awake bruxism susceptibility, clinical presentation, and patients' perceived stress level.
methodsThe study group included 104 patients with probable awake bruxism and 191 population controls. Patients underwent dental examination concerning the symptoms of bruxism and psychological testing. Genotyping was performed using HRMA and sequencing. Statistical analyses were conducted, and P values below 0.05 were considered statistically significant.
resultsWe observed a positive correlation of measured stress level and pathological teeth attrition in the anterior segment (r = 0.45, P < 0.001), enamel attritions (r = 0.44, P < 0.001), tongue impressions (r = 0.50, P < 0.001) and posterior teeth attrition (r = 0.27, P = 0.005). Moreover, the c.196A variant (p.66Met) of the BDNF gene and c.1397-31392G allele of the NTRK2 gene were present with elevated frequency, comparing to controls.
conclusionsThis study hence the thesis that perceived stress level is a substantial contributing factor to awake bruxism occurrence and its clinical manifestations. Moreover, sequence variants in genes related to stress coping may be correlated with awake bruxism's susceptibility via elevated perceived stress level.
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