Evidence map›Paper›PMID 34610653›Full record

ArticleAnnals of coloproctology2022

Initial local excision for clinical T1 rectal cancer showed comparable overall survival despite high local recurrence rate: a propensity-matched analysis.

Jong Hee Hyun, Mohamed K Alhanafy, Hyoung-Chul Park, Su Min Park, Sung-Chan Park, Dae Kyung Sohn, Duck-Woo Kim, Sung-Bum Kang, Seung-Yong Jeong, Kyu Joo Park and 1 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of coloproctology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07341126 (Surveillance Digital Rectoscopy After Local Excision of Rectal Tumours), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07341126 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Surveillance Digital Rectoscopy After Local Excision of Rectal Tumours

TypeobservationalSponsorUniversity of EdinburghRan2026 to 2027Enrolled30ConditionsBowel Cancer, Polyp Rectal, Rectal Cancer, Rectal AdenocarcinomaArmsLumenEye X1 digital rectoscope
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jong Hee HyunCenter for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.
Mohamed K AlhanafyCenter for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.
Hyoung-Chul ParkCenter for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.
Su Min ParkCenter for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.
Sung-Chan ParkCenter for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.
Dae Kyung SohnCenter for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.
Duck-Woo KimDepartment of Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
Sung-Bum KangDepartment of Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
Seung-Yong JeongDepartment of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Kyu Joo ParkDepartment of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Jae Hwan OhCenter for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.
National Cancer Center · KRSeoul National University Bundang Hospital · KRSeoul National University Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeLocal excision (LE) is an alternative initial treatment for clinical T1 rectal cancer, and has avoided potential morbidity. This study aimed to evaluate the clinical outcomes of LE compared with total mesorectal excision (TME) for clinical T1 rectal cancer.

methodsBetween January 2000 and December 2011, we retrospectively reviewed from multicenter data in patients with clinically suspected T1 rectal cancer treated with either LE or TME. Of 1,071 patients, 106 were treated with LE and 965 were treated with TME. The data were analyzed using propensity score matching, with each group comprising 91 patients.

resultsAfter propensity score matching, the median follow-up time was 60.8 months (range, 0.6-150.6 months). After adjustment for the necessary variables, patients who underwent LE showed a significantly higher local recurrence rate than did those who underwent TME; however, there were no differences in disease-free survival and overall survival. In the multivariate analysis, age (hazard ratio [HR], 9.620; 95% confidence interval [CI], 3.415-27.098; P<0.001) and angiolymphatic invasion (HR, 3.63; 95% confidence interval, 1.33-9.89; P=0.012) were independently associated with overall survival. However, LE was neither associated with overall survival nor disease-free survival.

conclusionLE for clinical T1 rectal cancer yielded a higher local recurrence rate than did TME. Nevertheless, LE provided comparable overall survival rate and can be proposed as an optional treatment in terms of organ-preserving strategies.

Indexed as

Local excisionPatient outcomeRectal cancerTotal mesorectal excision

Identifiers

PMID34610653
PMCPMC9021851
OpenAlexW3204720036

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.