ArticleCell reports2021
Neurovascular dynamics of repeated cortical spreading depolarizations after acute brain injury.
Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 45 citations in OpenAlex.
- Methods, Trade-offs, and Opportunities in High-speed Optical Microscopy for Neural Voltage imaging.Nature photonics · 2026Article
- A delayed endothelial-glial mechanism for CGRP-induced migraine.The journal of headache and pain · 2026Review
- Spreading depolarization: A wave that precedes and drives cerebral ischemic cell death-Target for neuroprotection.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Initiation site of experimentally-evoked spreading depolarizations influence tissue outcomes in a murine stroke model.Experimental neurology · 2026Article
- Hemodynamic and Electrophysiological Progression of the Rose Bengal Photothrombotic Stroke Model in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Predictive Utility of Cerebral Blood Flow Transients in Experimental Stroke.Translational stroke research · 2026Article
- The protocol for mesoscopic wide-field optical imaging in mice: from zero to hero.Biology methods & protocols · 2026Review
- Biphasic acclimation for simultaneous wide-field fluorescent CaImaging neuroscience (Cambridge, Mass.) · 2026Article
- Calcium Imaging in Vivo: How to Correctly Select and Apply Fiber Optic Photometric Indicators.Organogenesis · 2025Review
- DWI-Positive Lesions in Acute Intracerebral Hemorrhage and Their Correlation With Small Vessel Disease: A Cohort Study.Neurology · 2025Article
- Longitudinal, simultaneous wide-field fluorescent Ca2+ imaging and fMRI in awake mice.bioRxiv : the preprint server for biology · 2025Article
- Initiation site of experimentally-evoked spreading depolarizations influence tissue outcomes in a murine stroke model.bioRxiv : the preprint server for biology · 2025Article
- Olfactory Bulb Pinprick Induction of Cortical Spreading Depolarizations.bioRxiv : the preprint server for biology · 2025Article
- State-of-the-art preclinical techniques to study the impact of spreading depolarizations in awake rodents.The journal of headache and pain · 2025Review
- Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans.Nature communications · 2025Article
- Contralesional hippocampal spreading depolarization promotes functional recovery after stroke.Nature communications · 2025Article
- Repetitive cortical spreading depolarizations are prolonged early after experimental traumatic brain injury.Experimental neurology · 2025Article
- All Three Supersystems-Nervous, Vascular, and Immune-Contribute to the Cortical Infarcts After Subarachnoid Hemorrhage.Translational stroke research · 2025Review
- Similarities in the Electrographic Patterns of Delayed Cerebral Infarction and Brain Death After Aneurysmal and Traumatic Subarachnoid Hemorrhage.Translational stroke research · 2025Review
- Role of astrocytes connexins - pannexins in acute brain injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Cortical spreading depolarizations (CSDs) are increasingly suspected to play an exacerbating role in a range of acute brain injuries, including stroke, possibly through their interactions with cortical blood flow. We use simultaneous wide-field imaging of neural activity and hemodynamics in Thy1-GCaMP6f mice to explore the neurovascular dynamics of CSDs during and following Rose Bengal-mediated photothrombosis. CSDs are observed in all mice as slow-moving waves of GCaMP fluorescence extending far beyond the photothrombotic area. Initial CSDs are accompanied by profound vasoconstriction and leave residual oligemia and ischemia in their wake. Later, CSDs evoke variable responses, from constriction to biphasic to vasodilation. However, CSD-evoked vasoconstriction is found to be more likely during rapid, high-amplitude CSDs in regions with stronger oligemia and ischemia, which, in turn, worsens after each repeated CSD. This feedback loop may explain the variable but potentially devastating effects of CSDs in the context of acute brain injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.