Evidence map›Paper›PMID 34610264›Full record

ArticleOpen biology2021

Time-optimized feeding is beneficial without enforced fasting.

Kevin P Kelly, Kate L J Ellacott, Heidi Chen, Owen P McGuinness, Carl Hirschie Johnson

Open access · goldAbstract read
In one paragraph

Article in Open biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Chrononutrition: Potential, Challenges, and Application in Managing Obesity.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Kevin P KellyDepartment of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA.
Kate L J EllacottInstitute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.
Heidi ChenDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Owen P McGuinnessDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA.
Carl Hirschie JohnsonDepartment of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA.ORCID 0000-0003-2878-3193
Vanderbilt University · USNashville Oncology Associates · USUniversity of Exeter · GB

Funding

Coordinating and Bioinformatics Unit for the MMPC/DiaCompU24DK076169 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2006 to 2018
$42.4M
NUTRITION, INFECTION AND HEPATIC CARBOHYDRATE METABOLISMR01DK043748 · NIDDK · VANDERBILT UNIVERSITY · PI MCGUINNESS, OWEN P · 1997 to 2018
$7.9M
Circadian Programs in BacteriaR01GM067152 · NIGMS · VANDERBILT UNIVERSITY · PI JOHNSON, CARL HIRSCHIE · 2003 to 2014
$3.9M
Circadian and Sleep Programming in Angelman Syndrome Mouse ModelsR01NS104497 · NINDS · VANDERBILT UNIVERSITY · PI JOHNSON, CARL HIRSCHIE · 2017 to 2020
$1.2M
Nutrition Infection and Hepatic Carbohydrate MetabolismR56DK043748 · NIDDK · VANDERBILT UNIVERSITY · PI MCGUINNESS, OWEN P · 2009 to 2009
$500k
Comprehensive Laboratory Animal Measurement System (CLAMS)S10RR028101 · NCRR · VANDERBILT UNIVERSITY · PI ELLACOTT, KATE LJ · 2010 to 2010
$202k
NCRR NIH HHS S10 RR028101NIDDK NIH HHS R01 DK043748NIDDK NIH HHS R56 DK043748NIDDK NIH HHS U24 DK076169NIGMS NIH HHS R01 GM067152NINDS NIH HHS R01 NS104497
6 · The paper itself

Abstract

Time-restricted feeding (TRF) studies underscore that

Indexed as

AnimalsCircadian ClocksCircadian RhythmCorticosteroneDiet, High-FatEnergy MetabolismFastingFeeding BehaviorLipid PeroxidationMaleMiceObesityCorticosteronecircadian rhythmsenergy expenditurefastinglipid metabolismrespiratory quotienttime-restricted feeding

Identifiers

PMID34610264
PMCPMC8492177
OpenAlexW3204522268

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.