Evidence map›Paper›PMID 34610112›Full record

ArticleBlood advances2021

Inhibiting casein kinase 2 sensitizes acute lymphoblastic leukemia cells to venetoclax via MCL1 degradation.

Juan Lázaro-Navarro, Helia Judith Pimentel-Gutiérrez, Anton Gauert, Anja I H Hagemann, Jassi Eisenschmid, Nicola Gökbuget, Binje Vick, Irmela Jeremias, Felix Seyfried, Lüder Hinrich Meyer and 11 more

Open access · goldAbstract read
In one paragraph

Article in Blood advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 1 country.

Juan Lázaro-NavarroDepartment of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-2324-7159
Helia Judith Pimentel-GutiérrezDepartment of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Anton GauertDepartment of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-3013-5374
Anja I H HagemannDepartment of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0001-5491-4607
Jassi EisenschmidFrankfurt Cancer Institute, Frankfurt, Germany.ORCID 0000-0002-8650-4247
Nicola GökbugetGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Binje VickGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Irmela JeremiasGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0003-1773-7677
Felix SeyfriedDepartment of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany; and.
Lüder Hinrich MeyerDepartment of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany; and.
Klaus-Michael DebatinDepartment of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany; and.ORCID 0000-0002-8397-1886
Kathrin RicherMedical Department II, Hematology/Oncology, University Medical Center Schleswig-Holstein, Campus Kiel, Germany.
Miriam BultmanMedical Department II, Hematology/Oncology, University Medical Center Schleswig-Holstein, Campus Kiel, Germany.
Martin NeumannGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Sonja HänzelmannGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Hubert ServeGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-8472-5516
Kathy AstrahantseffDepartment of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Michael A RiegerGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Cornelia EckertDepartment of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0003-1039-2872
Claudia D BaldusGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Lorenz BastianGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-1487-9437
German Cancer Research Center · DEGoethe University Frankfurt · DEUniversität Ulm · DECharité - Universitätsmedizin Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Casein Kinase IIPrecursor Cell Lymphoblastic Leukemia-LymphomaBridged Bicyclo Compounds, HeterocyclicHumansMyeloid Cell Leukemia Sequence 1 ProteinSulfonamidesBridged Bicyclo Compounds, HeterocyclicCasein Kinase IIMCL1 protein, humanMyeloid Cell Leukemia Sequence 1 ProteinSulfonamidesvenetoclax

Identifiers

PMID34610112
PMCPMC8714730
OpenAlexW3203894261

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.