SynthesisPLoS neglected tropical diseases2021
Predictive markers for the early prognosis of dengue severity: A systematic review and meta-analysis.
Synthesis in PLoS neglected tropical diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 36 papers, 2 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Neutrophil-to-lymphocyte ratio for the clinical management of dengue: a systematic review and meta-analysis.Frontiers in epidemiology · 2026Pooled it
- Early biomarkers for prediction of severe manifestations of dengue fever: a systematic review and a meta-analysis.Scientific reports · 2023Pooled it
- Longitudinal Trajectories of Platelet Indices Across Dengue Severity in Children: A Linear Mixed-Model Analysis.Cureus · 2026Article
- AI-Driven Approaches for the Detection, Classification, and Surveillance of Viral Pathogens: Current Advances, Challenges, and Future Directions.Pathogens (Basel, Switzerland) · 2026Review
- Exploring potential gene signatures in dengue through machine learning and deep learning approaches.Virus genes · 2026Article
- Clinical characteristics of thrombocytopenia in tropical diseases and management in resource-limited settings.Research and practice in thrombosis and haemostasis · 2026Review
- Monocyte TLR2/4 as predictive biomarkers for progression from dengue warning signs to severe disease.Frontiers in immunology · 2026Article
- Early and late biomarkers as predictors of severe dengue: a comprehensive umbrella review protocol.BMJ open · 2025Article
- Clinical characteristics, complications and outcomes of critically ill patients with Dengue in Brazil, 2012-2024: A nationwide, multicenter cohort study.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2025Article
- Platelet dynamics and thrombocytopenia in dengue fever: A prospective cohort study from Shenzhen, China.New microbes and new infections · 2025Article
- Elevated liver enzyme (AST and ALT) as biomarkers for severe dengue in Nepalese patients: a cross-sectional study.BMC infectious diseases · 2025Article
- Prognostic Indicators of Severe Dengue Infection in Adult Patients in Thailand.Tropical medicine and infectious disease · 2025Article
- Rotational thromboelastometry performed during the febrile phase of dengue in predicting progression to critical phase: A prospective case control study.IJID regions · 2025Article
- Portable Point-of-Care Diagnosis Platforms and Emerging Predictive Biomarkers for Rapid Detection of Severe Dengue Viral Infection.ACS sensors · 2025Review
- Article
- Excessive fluid resuscitation is associated with intensive care unit mortality in Pakistani patients with dengue shock syndrome.Acute and critical care · 2025Article
- Serum Ferritin Level in Children with Severe Dengue Infection and Its Association with Outcome: A Single-center Prospective Cohort Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- Leukopenia and thrombocytopenia in dengue patients presenting in the emergency department of a tertiary center in Nepal: a cross-sectional study.BMC infectious diseases · 2025Article
- Clinical features and laboratory indicators of dengue infection in China: a retrospective study of adult patients in a hospital of traditional Chinese medicine.Frontiers in medicine · 2025Article
- Oxidized HDL as a Novel Predictive Biomarker in Conjunction with Selected Inflammatory Variables in Severe Dengue Fever Patients from Lahore, Pakistan.Current molecular medicine · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 11 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPredictive markers represent a solution for the proactive management of severe dengue. Despite the low mortality rate resulting from severe cases, dengue requires constant examination and round-the-clock nursing care due to the unpredictable progression of complications, posing a burden on clinical triage and material resources. Accordingly, identifying markers that allow for predicting disease prognosis from the initial diagnosis is needed. Given the improved pathogenesis understanding, myriad candidates have been proposed to be associated with severe dengue progression. Thus, we aim to review the relationship between the available biomarkers and severe dengue. METHODOLOGY: We performed a systematic review and meta-analysis to compare the differences in host data collected within 72 hours of fever onset amongst the different disease severity levels. We searched nine bibliographic databases without restrictive criteria of language and publication date. We assessed risk of bias and graded robustness of evidence using NHLBI quality assessments and GRADE, respectively. This study protocol is registered in PROSPERO (CRD42018104495). PRINCIPAL
findingsOf 4000 records found, 40 studies for qualitative synthesis, 19 for meta-analysis. We identified 108 host and viral markers collected within 72 hours of fever onset from 6160 laboratory-confirmed dengue cases, including hematopoietic parameters, biochemical substances, clinical symptoms, immune mediators, viral particles, and host genes. Overall, inconsistent case classifications explained substantial heterogeneity, and meta-analyses lacked statistical power. Still, moderate-certainty evidence indicated significantly lower platelet counts (SMD -0.65, 95% CI -0.97 to -0.32) and higher AST levels (SMD 0.87, 95% CI 0.36 to 1.38) in severe cases when compared to non-severe dengue during this time window.
conclusionThe findings suggest that alterations of platelet count and AST level-in the first 72 hours of fever onset-are independent markers predicting the development of severe dengue.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.