Evidence map›Paper›PMID 34609949›Full record

ArticleJournal of psychiatry & neuroscience : JPN2021

Personality changes with subcallosal cingulate deep brain stimulation in patients with treatment-resistant depression.

Rajamannar Ramasubbu, Laina McAusland, Sanchit Chopra, Darren L Clark, Bettina H Bewernick, Zelma H T Kiss

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 4 countries.

Rajamannar RamasubbuFrom the Department of Psychiatry, University of Calgary, Calgary, Alberta (Ramasubbu, McAusland, Chopra, Clark, Kiss); the Clinical Neurosciences, University of Calgary, Calgary, Alberta (Ramasubbu, McAusland, Clark, Kiss); the Mathison Centre for Mental Health Research & Education, University of Calgary, Calgary, Alberta (Ramasubbu, McAusland, Chopra, Clark, Kiss); the Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta (Ramasubbu, Chopra, Clark, Kiss); The Department of Geriatric Psychiatry and Section for Medical Psychology of the Department of Psychiatry and Psychotherapy, University Hospital Bonn, Germany (Bewernick) rramasub@ucalgary.ca.
Laina McAuslandFrom the Department of Psychiatry, University of Calgary, Calgary, Alberta (Ramasubbu, McAusland, Chopra, Clark, Kiss); the Clinical Neurosciences, University of Calgary, Calgary, Alberta (Ramasubbu, McAusland, Clark, Kiss); the Mathison Centre for Mental Health Research & Education, University of Calgary, Calgary, Alberta (Ramasubbu, McAusland, Chopra, Clark, Kiss); the Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta (Ramasubbu, Chopra, Clark, Kiss); The Department of Geriatric Psychiatry and Section for Medical Psychology of the Department of Psychiatry and Psychotherapy, University Hospital Bonn, Germany (Bewernick).
Sanchit ChopraFrom the Department of Psychiatry, University of Calgary, Calgary, Alberta (Ramasubbu, McAusland, Chopra, Clark, Kiss); the Clinical Neurosciences, University of Calgary, Calgary, Alberta (Ramasubbu, McAusland, Clark, Kiss); the Mathison Centre for Mental Health Research & Education, University of Calgary, Calgary, Alberta (Ramasubbu, McAusland, Chopra, Clark, Kiss); the Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta (Ramasubbu, Chopra, Clark, Kiss); The Department of Geriatric Psychiatry and Section for Medical Psychology of the Department of Psychiatry and Psychotherapy, University Hospital Bonn, Germany (Bewernick).
Darren L ClarkFrom the Department of Psychiatry, University of Calgary, Calgary, Alberta (Ramasubbu, McAusland, Chopra, Clark, Kiss); the Clinical Neurosciences, University of Calgary, Calgary, Alberta (Ramasubbu, McAusland, Clark, Kiss); the Mathison Centre for Mental Health Research & Education, University of Calgary, Calgary, Alberta (Ramasubbu, McAusland, Chopra, Clark, Kiss); the Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta (Ramasubbu, Chopra, Clark, Kiss); The Department of Geriatric Psychiatry and Section for Medical Psychology of the Department of Psychiatry and Psychotherapy, University Hospital Bonn, Germany (Bewernick).
Bettina H BewernickFrom the Department of Psychiatry, University of Calgary, Calgary, Alberta (Ramasubbu, McAusland, Chopra, Clark, Kiss); the Clinical Neurosciences, University of Calgary, Calgary, Alberta (Ramasubbu, McAusland, Clark, Kiss); the Mathison Centre for Mental Health Research & Education, University of Calgary, Calgary, Alberta (Ramasubbu, McAusland, Chopra, Clark, Kiss); the Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta (Ramasubbu, Chopra, Clark, Kiss); The Department of Geriatric Psychiatry and Section for Medical Psychology of the Department of Psychiatry and Psychotherapy, University Hospital Bonn, Germany (Bewernick).
Zelma H T KissFrom the Department of Psychiatry, University of Calgary, Calgary, Alberta (Ramasubbu, McAusland, Chopra, Clark, Kiss); the Clinical Neurosciences, University of Calgary, Calgary, Alberta (Ramasubbu, McAusland, Clark, Kiss); the Mathison Centre for Mental Health Research & Education, University of Calgary, Calgary, Alberta (Ramasubbu, McAusland, Chopra, Clark, Kiss); the Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta (Ramasubbu, Chopra, Clark, Kiss); The Department of Geriatric Psychiatry and Section for Medical Psychology of the Department of Psychiatry and Psychotherapy, University Hospital Bonn, Germany (Bewernick).
Allen Institute for Brain Science · USCentre for Mental Health · GBUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDeep brain stimulation (DBS) is a promising investigational approach for treatment-resistant depression. However, reports suggesting changes in personality with DBS for movement disorders have raised clinical and ethical concerns. We prospectively examined changes in personality dimensions and antidepressant response to subcallosal cingulate (SCC)-DBS for treatment-resistant depression.

methodsTwenty-two patients with treatment-resistant depression underwent SCC-DBS. We used the NEO Five-Factor Inventory for personality assessment at baseline and every 3 months until 15 months post-DBS. We assessed depression severity monthly using the Hamilton Depression Rating Scale.

resultsWe found a significant decrease in neuroticism ( LIMITATIONS: Limitations included a small sample size, a lack of sham control and the use of subjective personality evaluation.

conclusionWe observed positive personality changes following SCC-DBS, with reduced neuroticism and increased extraversion related to clinical improvement in depression, suggesting a state effect. As well, pretreatment levels of openness and agreeableness may have predicted subsequent response to DBS. The NEO Five-Factor Inventory assessment may have a role in clinical decision-making and prognostic evaluation in patients with treatment-resistant depression who undergo SCC-DBS.

Indexed as

Deep Brain StimulationGyrus CinguliPersonalityAdultAgedDepressionDepressive Disorder, Treatment-ResistantFemaleHumansMaleMiddle AgedYoung Adult

Identifiers

PMID34609949
PMCPMC8519494
OpenAlexW3194273718

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.