Evidence map›Paper›PMID 34609921›Full record

ArticleThe neuroradiology journal2022

Heterogeneity between proximal and distal aspects of occlusive thrombi on pretreatment imaging in acute ischemic stroke.

Tetsuya Hashimoto, Takenobu Kunieda, Tristan Honda, Fabien Scalzo, Latisha K Sharma, Jason D Hinman, Neal M Rao, May Nour, Mersedeh Bahr-Hosseini, Jeffrey L Saver and 2 more

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In one paragraph

Article in The neuroradiology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Tetsuya HashimotoDepartment of Neurology, University of California, Los Angeles, USA.ORCID https://orcid.org/0000-0002-8121-0215
Takenobu KuniedaDepartment of Neurology, University of California, Los Angeles, USA.
Tristan HondaDepartment of Neurology, University of California, Los Angeles, USA.
Fabien ScalzoDepartment of Neurology, University of California, Los Angeles, USA.
Latisha K SharmaDepartment of Neurology, University of California, Los Angeles, USA.
Jason D HinmanDepartment of Neurology, University of California, Los Angeles, USA.
Neal M RaoDepartment of Neurology, University of California, Los Angeles, USA.
May NourDepartment of Neurology, University of California, Los Angeles, USA.
Mersedeh Bahr-HosseiniDepartment of Neurology, University of California, Los Angeles, USA.
Jeffrey L SaverDepartment of Neurology, University of California, Los Angeles, USA.
Radoslav RaychevDepartment of Neurology, University of California, Los Angeles, USA.
David S LiebeskindDepartment of Neurology, University of California, Los Angeles, USA.
University of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe potential heterogeneity in occlusive thrombi caused by in situ propagation by secondary thrombosis after embolic occlusion could obscure the characteristics of original thrombi, preventing the clarification of a specific thrombus signature for the etiology of ischemic stroke. We aimed to investigate the heterogeneity of occlusive thrombi by pretreatment imaging.

methodsAmong consecutive stroke patients with acute embolic anterior circulation large vessel occlusion treated with thrombectomy, we retrospectively reviewed 104 patients with visible occlusive thrombi on pretreatment non-contrast computed tomography admitted from January 2015 to December 2018. A region of interest was set on the whole thrombus on non-contrast computed tomography under the guidance of computed tomography angiography. The region of interest was divided equally into the proximal and distal segments and the difference in Hounsfield unit densities between the two segments was calculated.

resultsHounsfield unit density in the proximal segment was higher than that in the distal segment (mean difference 4.45;

conclusionsThe difference in density between the proximal and distal segments increased as thrombi became longer and decreased as thrombi became older after embolic occlusion. This time/length-dependent thrombus heterogeneity between the two segments is suggestive of secondary thrombosis initially occurring on the proximal side of the occlusion.

Indexed as

Brain IschemiaIschemic StrokeStrokeThrombosisHumansRetrospective StudiesThrombectomyTomography, X-Ray ComputedArterial occlusive diseasesbrain ischemiacerebral arteriesembolismhemodynamicsneuroimagingthrombosis

Identifiers

PMID34609921
PMCPMC9244745
OpenAlexW3204447823

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.