Evidence map›Paper›PMID 34609702›Full record

ArticleJournal of cancer survivorship : research and practice2022

Physiological and psychosocial correlates of cancer-related fatigue.

Callum G Brownstein, Rosemary Twomey, John Temesi, James G Wrightson, Tristan Martin, Mary E Medysky, S Nicole Culos-Reed, Guillaume Y Millet

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Journal of cancer survivorship : research and practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 4 pooled it
2.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Effectiveness of exercise interventions in patients with colorectal cancer during adjuvant chemotherapy: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
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  7. From traditional warming and tonifying to psychoneuroimmunology: theoretical reconstruction and clinical application of moxibustion for cancer-related fatigue.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Review
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  10. Toward precision rehabilitation: a latent profile analysis of social support as a buffer against fatigue and reduced physical activity in breast cancer chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  16. Fatigue of Cancer is Distinctly Different than the Fatigue of Chronic Kidney Disease.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Callum G BrownsteinInter-University Laboratory of Human Movement Biology, Univ Lyon, UJM-Saint-Etienne, 7424, F-42023, Saint-Etienne, EA, France.
Rosemary TwomeyFaculty of Kinesiology, University of Calgary, Calgary, Canada.
John TemesiFaculty of Kinesiology, University of Calgary, Calgary, Canada.
James G WrightsonFaculty of Kinesiology, University of Calgary, Calgary, Canada.
Tristan MartinFaculty of Kinesiology, University of Calgary, Calgary, Canada.
Mary E MedyskyFaculty of Kinesiology, University of Calgary, Calgary, Canada.
S Nicole Culos-ReedFaculty of Kinesiology, University of Calgary, Calgary, Canada.
Guillaume Y MilletInter-University Laboratory of Human Movement Biology, Univ Lyon, UJM-Saint-Etienne, 7424, F-42023, Saint-Etienne, EA, France. guillaume.millet@univ-st-etienne.fr.ORCID 0000-0002-6395-0762
University of Calgary · CAUniversité Claude Bernard Lyon 1 · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCancer-related fatigue (CRF) is a common and distressing symptom of cancer that may persist for years following treatment completion. However, little is known about the pathophysiology of CRF. Using a comprehensive group of gold-standard physiological and psychosocial assessments, this study aimed to identify correlates of CRF in a heterogenous group of cancer survivors.

methodsUsing a cross-sectional design to determine the physiological and psychosocial correlates of CRF, ninety-three cancer survivors (51 fatigued, 42 non-fatigued) completed assessments of performance fatigability (i.e. the decline in muscle strength during cycling), cardiopulmonary exercise testing, venous blood samples for whole blood cell count and inflammatory markers and body composition. Participants also completed questionnaires measuring demographic, treatment-related, and psychosocial variables.

resultsPerformance fatigability, time-to-task-failure, peak oxygen uptake (V̇O

conclusionsThe present study utilised a comprehensive group of gold-standard physiological and psychosocial assessments and the results give potential insight into the mechanisms underpinning the association between physical inactivity, physical deconditioning and CRF. IMPLICATIONS FOR CANCER SURVIVORS: Given the associations between CRF and both physiological and psychosocial measures, this study identifies targets that can be measured by rehabilitation professionals and used to guide tailored interventions to reduce fatigue.

Indexed as

Cancer SurvivorsNeoplasmsCross-Sectional StudiesFatigueHumansSurveys and QuestionnairesTumor Necrosis Factor-alphaTumor Necrosis Factor-alphaAnthropometryCancer-related fatigueExerciseFatigabilityInflammation

Identifiers

PMID34609702
OpenAlexW3201179860

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.