Evidence map›Paper›PMID 34609662›Full record

ArticleClinical rheumatology2022

Prevalence, clinical features, risk factors, and outcomes of SLE patients with aortic aneurysm: a cross-sectional retrospective study in a Chinese single center.

Ju Zhang, Jie Gao, Ruina Kong, Chenxin Cheng, Qian Chen, Yunxia Xia, Xiaofang Li, Ti Zhang, Qing Cai

Abstract read
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In one paragraph

Article in Clinical rheumatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ju Zhang *Department of Rheumatology and Immunology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Jie Gao *Department of Rheumatology and Immunology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Ruina Kong *Department of Rheumatology and Immunology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Chenxin ChengDepartment of Health Statistics, Second Military Medical University, Shanghai, China.
Qian ChenDepartment of Rheumatology and Immunology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Yunxia XiaDepartment of Rheumatology and Immunology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Xiaofang LiDepartment of Rheumatology and Immunology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Ti ZhangNational Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China. drteezhang@163.com.ORCID http://orcid.org/0000-0002-1824-0753
Qing CaiDepartment of Rheumatology and Immunology, Changhai Hospital, Second Military Medical University, Shanghai, China. caiqing_2011@126.com.
Second Military Medical University · CNNanjing General Hospital of Nanjing Military Command · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe prevalence, clinical features, and outcomes of patients with systemic lupus erythematosus (SLE) complicated with or without aortic aneurysm (AA) were compared in a Chinese single-center cohort.

methodsIncluded in this study were SLE patients who received treatment at Shanghai Changhai Hospital between 2000 and 2020. The prevalence, clinical features, and outcomes of these SLE patients with or without AA were compared by Student's t-tests or Fisher's exact tests as appropriate. Risk factors associated with AA occurrence in SLE were evaluated by univariable and multivariable logistic regression analyses. The survival analysis between SLE patients with or without AA was conducted by the Kaplan-Meier method.

resultsOf the 1843 SLE patients included in this study, 16 (0.86%) were identified as having AA, and 160 of the remaining 1825 SLE patients without AA were selected as a simple random sample for comparison. The SLE patients with AA showed a higher proportion of smoking and hypertension as compared with those with no AA. Multivariable logistic regression analysis showed that a long SLE duration and anti-RNP positivity were two independent risk factors associated with AA occurrence in SLE patients. The log rank test showed that SLE patients with AA had a significantly higher risk of progression to death. Renal disorder was associated with an even poorer outcome in SLE patients with AA.

conclusionThe incidence of AA in SLE patients may be underestimated. The association between AA and SLE, especially in patients with multiple risk factors, should not be ignored. Key Points • The risk of SLE patients developing AA may be higher than that previously estimated. • The risk of SLE patients especially with multiple risk factors developing AA should not be ignored. • The diagnosis of AA should not be forgot when SLE patients present with chest, back, or abdominal symptoms with unexplained causes.

Indexed as

Aortic AneurysmLupus Erythematosus, SystemicChinaCross-Sectional StudiesHumansPrevalenceRetrospective StudiesRisk FactorsAnti-RNP antibodyAortic aneurysmSystemic lupus erythematosus (SLE)

Identifiers

PMID34609662
OpenAlexW3201886661

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.