Evidence map›Paper›PMID 34609603›Full record

ArticleJournal of neurology2022

Case report: cerebral sinus vein thrombosis in two patients with AstraZeneca SARS-CoV-2 vaccination.

Mathias Fousse, David Schub, Fatma Merzou, Klaus Fassbender, Martina Sester, Michael Kettner, Piergiorgio Lochner, Tina Schmidt, João Reinoldo Goi Júnior

Abstract readCase Reports
In one paragraph

Article in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mathias FousseDepartment of Neurology, Saarland University Medical Center, Kirrbergerstrasse 90, 66421, Homburg, Saarland, Germany. mathias.fousse@uks.eu.ORCID http://orcid.org/0000-0001-5489-1492
David SchubDepartment of Transplant and Infection Immunology, Saarland University Medical Center, Homburg, Saarland, Germany.
Fatma MerzouDepartment of Neurology, Saarland University Medical Center, Kirrbergerstrasse 90, 66421, Homburg, Saarland, Germany.
Klaus FassbenderDepartment of Neurology, Saarland University Medical Center, Kirrbergerstrasse 90, 66421, Homburg, Saarland, Germany.
Martina SesterDepartment of Transplant and Infection Immunology, Saarland University Medical Center, Homburg, Saarland, Germany.
Michael KettnerDepartment of Neuroradiology, Saarland University Medical Center, Homburg, Saarland, Germany.
Piergiorgio LochnerDepartment of Neurology, Saarland University Medical Center, Kirrbergerstrasse 90, 66421, Homburg, Saarland, Germany.
Tina SchmidtDepartment of Transplant and Infection Immunology, Saarland University Medical Center, Homburg, Saarland, Germany.
João Reinoldo Goi JúniorDepartment of Neurology, Saarland University Medical Center, Kirrbergerstrasse 90, 66421, Homburg, Saarland, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SARS-CoV-2 infection is associated with an increased rate of thromboembolic events and mortality. Different vaccines are globally used to limit the pandemic. In this report, we present the case of two young female patients with newly diagnosed cerebral sinus vein thrombosis occurring after injection of the vector-based ChAdOx1 vaccine. Both patients presented with unusual headache only. The two of them used an estrogen-containing contraception, had had a history of deep venous thrombosis, and both had MTHFR mutations. Both patients developed SARS-CoV-2 specific humoral and cellular immunity including both CD4 and CD8 T cells. This rare, but serious complication needs to be considered after vaccination of young females, even if there is no evidence of heparin-induced thrombocytopenia.

Indexed as

COVID-19ThrombosisChAdOx1 nCoV-19COVID-19 VaccinesFemaleHumansSARS-CoV-2VaccinationChAdOx1 nCoV-19COVID-19 VaccinesCerebral sinus vein thrombosisChAdOx1COVID-19SARS-CoV-2Vaccination

Identifiers

PMID34609603
PMCPMC8491181

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.