Evidence map›Paper›PMID 34609508›Full record

ReviewCardiovascular research2021

Cardiovascular consequences of viral infections: from COVID to other viral diseases.

Heinz-Peter Schultheiss, Christian Baumeier, Heiko Pietsch, C-Thomas Bock, Wolfgang Poller, Felicitas Escher

Open access · greenAbstract readReview
In one paragraph

Review in Cardiovascular research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Heinz-Peter SchultheissInstitute of Cardiac Diagnostics and Therapy, IKDT GmbH, Berlin, Germany.
Christian BaumeierInstitute of Cardiac Diagnostics and Therapy, IKDT GmbH, Berlin, Germany.
Heiko PietschInstitute of Cardiac Diagnostics and Therapy, IKDT GmbH, Berlin, Germany.ORCID 0000-0002-1661-159X
C-Thomas BockDivision of Viral Gastroenteritis and Hepatitis Pathogens and Enteroviruses, Department of Infectious Diseases, Robert Koch Institute, Berlin 13353 Germany.ORCID 0000-0002-2773-486X
Wolfgang PollerDZHK (German Centre for Cardiovascular Research), Berlin, Germany.ORCID 0000-0002-2805-6634
Felicitas EscherInstitute of Cardiac Diagnostics and Therapy, IKDT GmbH, Berlin, Germany.ORCID 0000-0003-0678-5681
Humboldt-Universität zu Berlin · DECS Diagnostics · DERobert Koch Institute · DE

Funding

EFRE 10169096ERA-Net on Cardiovascular Diseases JTC2016-40-158Investitionsbank Berlin
6 · The paper itself

Abstract

Infection of the heart muscle with cardiotropic viruses is one of the major aetiologies of myocarditis and acute and chronic inflammatory cardiomyopathy (DCMi). However, viral myocarditis and subsequent dilated cardiomyopathy is still a challenging disease to diagnose and to treat and is therefore a significant public health issue globally. Advances in clinical examination and thorough molecular genetic analysis of intramyocardial viruses and their activation status have incrementally improved our understanding of molecular pathogenesis and pathophysiology of viral infections of the heart muscle. To date, several cardiotropic viruses have been implicated as causes of myocarditis and DCMi. These include, among others, classical cardiotropic enteroviruses (Coxsackieviruses B), the most commonly detected parvovirus B19, and human herpes virus 6. A newcomer is the respiratory virus that has triggered the worst pandemic in a century, SARS-CoV-2, whose involvement and impact in viral cardiovascular disease is under scrutiny. Despite extensive research into the pathomechanisms of viral infections of the cardiovascular system, our knowledge regarding their treatment and management is still incomplete. Accordingly, in this review, we aim to explore and summarize the current knowledge and available evidence on viral infections of the heart. We focus on diagnostics, clinical relevance and cardiovascular consequences, pathophysiology, and current and novel treatment strategies.

Indexed as

AnimalsAntiviral AgentsCardiomyopathy, DilatedCOVID-19COVID-19 Drug TreatmentGenetic TherapyHost-Pathogen InteractionsHumansMyocarditisParvoviridae InfectionsParvovirus B19, HumanSARS-CoV-2Antiviral AgentsAdvanced diagnosticsInflammatory cardiomyopathyMyocarditisTreatment strategiesViral infections

Identifiers

PMID34609508
PMCPMC8500164
OpenAlexW3204655764

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.