ArticleRomanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
Association between burnout and immunological and endocrine alterations.
Article in Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05510414 (Evaluation of a Psychological Capital Intervention to Alleviate Burnout and Regulate Immunity Among Oncology Nurses), which is not on this map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of a Psychological Capital Intervention to Alleviate Burnout and Regulate Immunity Among Oncology Nurses: a Randomized Controlled Trial
Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Low Battery Alarm; A Scoping Review of Autistic Burnout.Journal of autism and developmental disorders · 2026Article
- Self-compassion as a well-being strategy against burnout among dentists: a controlled intervention study.BMC psychology · 2026Article
- The Biological Clock Influenced by Burnout, Hormonal Dysregulation and Circadian Misalignment: A Systematic Review.Clocks & sleep · 2025Review
- Neural Correlates of Burnout Syndrome Based on Electroencephalography (EEG)-A Mechanistic Review and Discussion of Burnout Syndrome Cognitive Bias Theory.Journal of clinical medicine · 2025Review
- Blood Metabolic Biomarkers of Occupational Stress in Healthcare Professionals: Discriminating Burnout Levels and the Impact of Night Shift Work.Clocks & sleep · 2025Article
- Urine Metabolomic Patterns to Discriminate the Burnout Levels and Night-Shift-Related Stress in Healthcare Professionals.Metabolites · 2025Article
- Concussion and the Autonomic, Immune, and Endocrine Systems: An Introduction to the Field and a Treatment Framework for Persisting Symptoms.Journal of personalized medicine · 2025Review
- Relationship between burnout and serum markers in military personnel in plateau and plain areas of China: a cross-sectional study.Frontiers in public health · 2025Article
- Quality of Life Predictors in a Group of Informal Caregivers during the COVID-19 Pandemic.Medicina (Kaunas, Lithuania) · 2023Article
- Caregiving for Dementia Patients during the Coronavirus Pandemic.Journal of clinical medicine · 2023Article
- A Cross-Level Study of the Consequences of Work Stress in Police Officers: Using Transformational Leadership and Group Member Interactions as an Example.Psychology research and behavior management · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWeather a psychological construct or a clinical entity, numerous studies have been focused on the biological link between stress, burnout, and biomarkers.
aimThe purpose of our study was to search the existing literature and summarize the immunological and endocrine alterations found in burnout patients and, also, to provide updated data for clinicians to use.
methodsWe performed a literature search in PubMed database using specific terms.
resultsThe primary focus of the literature seems to be the hypothalamic-pituitary-adrenal (HPA) axis, which may be affected due to chronic stress, which can be investigated by measuring hormonal responsiveness [corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), cortisol, prolactin, thyroid hormones]. An important challenge that this field is faced with is the pulsatile and diurnal fluctuation of them, which may not always be considered and the heterogeneity of burnout measurements. Many studies have explored the linking pathways between the immune system and chronic stress, but only a few have specifically evaluated this process for future diagnostic or prognostic biomarkers.
conclusionsBurnout has cumulative effects on our body and stress does not affect us in a singular direction, on the contrary, significant clinical implications are found, not only microscopic, but affective symptoms leading to anxiety and depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.