ArticleeLife2021
β-Catenin-NF-κB-CFTR interactions in cholangiocytes regulate inflammation and fibrosis during ductular reaction.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.0field-weighted citation impact, top 11% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- miR-140-5p Inhibition alleviates LPS-induced cholangitis in rats and is associated with modulation of the NF-κB signaling pathway.Scientific reports · 2026Article
- Novel Mechanistic Insights into Primary Biliary Cholangitis: From Pathogenesis to Mesenchymal Stem Cell-Mediated Repair.Biomedicines · 2026Review
- Loss of β-catenin in cholangiocytes promotes hepatocyte reprogramming and vascular remodeling during murine cholestasis.Cell communication and signaling : CCS · 2026Article
- Bioinformatics identification of key genes correlating NOD1 and Endoplasmic Reticulum stress in Hepatitis B virus-induced acute liver failure.Scientific reports · 2025Article
- Central role for cholangiocyte pathobiology in cholestatic liver diseases.Hepatology (Baltimore, Md.) · 2025Review
- Wnt/β-Catenin Signaling in Liver Pathobiology.Annual review of pathology · 2025Review
- Proteomics profiling of inflammatory responses to elexacaftor/tezacaftor/ivacaftor in cystic fibrosis.Frontiers in immunology · 2025Article
- Loss of β-catenin reveals a role for glutathione in regulating oxidative stress during cholestatic liver disease.Hepatology communications · 2024Article
- Review
- Analysis of subsets and localization of macrophages in skin lesions and peripheral blood of patients with keloids.Heliyon · 2024Article
- Heat shock factor 1 promotes neurite outgrowth and suppresses inflammation in the severed spinal cord of geckos.Neural regeneration research · 2023Article
- Ductular reaction in non-alcoholic fatty liver disease: When Macbeth is perverted.World journal of hepatology · 2023Review
- Cellular and transcriptional heterogeneity in the intrahepatic biliary epithelium.Gastro hep advances · 2023Article
- Ductular Reaction and Liver Regeneration: Fulfilling the Prophecy of Prometheus!Cellular and molecular gastroenterology and hepatology · 2023Article
- CFTR and Gastrointestinal Cancers: An Update.Journal of personalized medicine · 2022Review
- Receptor Guanylyl Cyclase C and Cyclic GMP in Health and Disease: Perspectives and Therapeutic Opportunities.Frontiers in endocrinology · 2022Review
- Article
Corrections and comments
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Authors and funding
18 authors at 1 institution in 2 countries.
Shikai Hu *School of Medicine, Tsinghua University, Beijing, China.
Jacquelyn O Russell *Department of Pathology, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, United States.
Silvia LiuDepartment of Pathology, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, United States.
Catherine CaoDepartment of Pathology, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, United States.
Jackson McGaugheyDepartment of Pathology, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, United States.
Ravi RaiDepartment of Pathology, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, United States.
Karis KosarDepartment of Pathology, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, United States.
Junyan TaoDepartment of Pathology, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, United States.
Edward HurleyDepartment of Pediatrics, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, United States.
Minakshi PoddarDepartment of Pathology, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, United States.
Sucha SinghDepartment of Pathology, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, United States.
Aaron BellDepartment of Pathology, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, United States.
Donghun ShinPittsburgh Liver Research Center, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, United States.ORCID 0000-0002-7975-9014
Reben RaemanDepartment of Pathology, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, United States.
Aatur D SinghiDepartment of Pathology, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, United States.
Kari Nejak-BowenDepartment of Pathology, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, United States.
Sungjin KoDepartment of Pathology, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, United States.
Satdarshan P MongaDepartment of Pathology, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, United States.ORCID 0000-0002-8437-3378
University of Pittsburgh Medical Center · US
Funding
Pittsburgh Liver Research CenterP30DK120531 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Shuchang Silvia Liu · 2019 to 2026
$10.9MRole of Wnt/Beta-Catenin Signaling in Liver DevelopmentR01DK062277 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Satdarshan Singh Monga · 2004 to 2026
$9.0MTargeting tumor metabolism and immune environment via beta-catenin: Towards precision medicine in HCCR01CA251155 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LUJAMBIO, AMAIA, MONGA, SATDARSHAN SINGH · 2020 to 2024
$3.1MDelineating Molecular Mechanisms Underlying Liver Progenitor Cell-Driven Liver RegenerationR01DK116993 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MONGA, SATDARSHAN SINGH, SHIN, DONGHUN · 2018 to 2021
$2.2MYap and beta-catenin interactions in liver: Implications in PathophysiologyR01CA204586 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, XIN, MONGA, SATDARSHAN SINGH · 2016 to 2020
$2.1MIdentifying therapeutic options for intrahepatic cholangiocarcinomaR01CA258449 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KO, SUNGJIN · 2021 to 2025
$1.6MTargeting beta-catenin in liver pathology: Novel Interactions, Novel ParadigmsR01DK100287 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MONGA, SATDARSHAN SINGH · 2013 to 2016
$1.3MElucidating the role of β-catenin signaling in liver progenitor cell-mediated liver regenerationF31DK115017 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RUSSELL, JACQUELYN OLIVIA · 2017 to 2018
$89kNCI NIH HHS R01 CA204586NCI NIH HHS R01 CA251155NCI NIH HHS R01 CA258449NIDDK NIH HHS F31 DK115017NIDDK NIH HHS P30 DK120531NIDDK NIH HHS R01 DK062277NIDDK NIH HHS R01 DK100287NIDDK NIH HHS R01 DK116993
Abstract
Expansion of biliary epithelial cells (BECs) during ductular reaction (DR) is observed in liver diseases including cystic fibrosis (CF), and associated with inflammation and fibrosis,
Indexed as
Animalsbeta CateninCystic Fibrosis Transmembrane Conductance RegulatorEpithelial CellsFibrosisInflammationMiceMice, TransgenicNF-kappa Bbeta CateninCftr protein, mouseCTNNB1 protein, mouseCystic Fibrosis Transmembrane Conductance RegulatorNF-kappa Bbeta-catenincholangiocytescystic fibrosisdevelopmental biologyductular reactionhumanliver fibrosismedicinemouseNF-κB
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.