Evidence map›Paper›PMID 34609279›Full record

ArticleeLife2021

A sex-specific evolutionary interaction between

Isabel Gamache, Marc-André Legault, Jean-Christophe Grenier, Rocio Sanchez, Eric Rhéaume, Samira Asgari, Amina Barhdadi, Yassamin Feroz Zada, Holly Trochet, Yang Luo and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 4 countries.

Isabel GamacheUniversité de Montréal, Montréal, Canada.ORCID 0000-0002-0613-0979
Marc-André LegaultUniversité de Montréal, Montréal, Canada.
Jean-Christophe GrenierMontreal Heart Institute, Montréal, Canada.
Rocio SanchezMontreal Heart Institute, Montréal, Canada.
Eric RhéaumeUniversité de Montréal, Montréal, Canada.
Samira AsgariCenter for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, United States.
Amina BarhdadiMontreal Heart Institute, Montréal, Canada.
Yassamin Feroz ZadaUniversité de Montréal Beaulieu-Saucier Pharmacogenomics Centre, Montréal, Canada.
Holly TrochetUniversité de Montréal, Montréal, Canada.
Yang LuoCenter for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, United States.
Leonid LeccaSocios En Salud, Lima, Peru.
Megan MurrayCenter for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, United States.
Soumya RaychaudhuriCenter for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, United States.
Jean-Claude TardifUniversité de Montréal, Montréal, Canada.
Marie-Pierre DubéUniversité de Montréal, Montréal, Canada.ORCID 0000-0001-8442-4393
Julie HussinUniversité de Montréal, Montréal, Canada.ORCID 0000-0003-4295-3339
Montreal Heart Institute · CABroad Institute · USBrigham and Women's Hospital · USHarvard University · USUniversité de Montréal · CA

Funding

Gerome Wide Association Study of Bacterial Determinants of Clinical Response in TuberculosisU19AI142793 · NIAID · HARVARD MEDICAL SCHOOL · PI MURRAY, MEGAN B · 2019 to 2023
$14.6M
CIHRMedical Research Council MC_PC_17228Medical Research Council MC_QA137853NIAID NIH HHS U19 AI142793
6 · The paper itself

Abstract

Pharmacogenomic studies have revealed associations between rs1967309 in the adenylyl cyclase type 9 (

Indexed as

Linkage DisequilibriumPolymorphism, Single NucleotideAdenylyl CyclasesAdultAgedAmidesAnticholesteremic AgentsBiological EvolutionCholesterol Ester Transfer ProteinsEstersFemaleGene Expression ProfilingHumansMaleMiddle AgedSex Factorsadenylate cyclase 9Adenylyl CyclasesAmidesAnticholesteremic AgentsCETP protein, humanCholesterol Ester Transfer ProteinsdalcetrapibEstersSulfhydryl Compoundscardiovascular diseasecomputational biologygeneticsgenomicshumanlinkage disequilibriumpharmacogenomicsphenotype associationspopulation geneticssystems biologytranscriptomics

Identifiers

PMID34609279
PMCPMC8594919
OpenAlexW3202958967

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.