Evidence map›Paper›PMID 34609072›Full record

ArticleJournal of cellular and molecular medicine2021

Hypoxia blocks ferroptosis of hepatocellular carcinoma via suppression of METTL14 triggered YTHDF2-dependent silencing of SLC7A11.

Zhuoyang Fan, Guowei Yang, Wei Zhang, Qian Liu, Guangqin Liu, Pingping Liu, Ligang Xu, Jianhua Wang, Zhiping Yan, Hong Han and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 157 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. mFrontiers in cell and developmental biology · 2026
    Review
  11. Hypoxia Triggers ALYREF-Mediated mThe Kaohsiung journal of medical sciences · 2026
    Article
  12. Review
  13. Inducing ferroptosis to improve cancer therapy: a promising tool for enhancing immunotherapy.Journal of experimental & clinical cancer research : CR · 2025
    Review
  14. Review
  15. Review
  16. Hypoxia-mediated mJournal of translational medicine · 2025
    Review
  17. Review
  18. Review
  19. Targeting RNA adenosine editing and modification enzymes for RNA therapeutics.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  20. Article

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Zhuoyang FanDepartment of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Guowei YangDepartment of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Wei ZhangDepartment of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Qian LiuDepartment of Pharmacology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Guangqin LiuDepartment of Pharmacology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Pingping LiuDepartment of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Ligang XuDepartment of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Jianhua WangDepartment of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Zhiping YanDepartment of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Hong HanDepartment of Ultrasound, Zhongshan Hospital of Fudan University, Shanghai, China.
Rong LiuDepartment of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Minfeng ShuDepartment of Pharmacology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.ORCID 0000-0003-0514-1892
Fudan University · CNShanghai Medical College of Fudan University · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Residue hepatocellular carcinoma (HCC) cells enduring hypoxic environment triggered by interventional embolization obtain more malignant potential with little clarified mechanism. The N

Indexed as

Amino Acid Transport System y+Carcinoma, HepatocellularCell Line, TumorEctopic Gene ExpressionFerroptosisGene Expression Regulation, NeoplasticGene Knockdown TechniquesHumansHypoxiaHypoxia-Inducible Factor 1, alpha SubunitLipid PeroxidationLiver NeoplasmsMethylationMethyltransferasesModels, BiologicalPrognosisAmino Acid Transport System y+HIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitMethyltransferasesMETTL14 protein, humanReactive Oxygen SpeciesRNA-Binding ProteinsRNA, MessengerSLC7A11 protein, humanYTHDF2 protein, humanferroptosishepatocellular carcinomahypoxiaMETTL14SLC7A11

Identifiers

PMID34609072
PMCPMC8572766
OpenAlexW3204550677

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.